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手机短信戒烟支持的成本效益:Txt2stop。

The cost-effectiveness of smoking cessation support delivered by mobile phone text messaging: Txt2stop.

机构信息

Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.

出版信息

Eur J Health Econ. 2013 Oct;14(5):789-97. doi: 10.1007/s10198-012-0424-5. Epub 2012 Sep 9.

Abstract

BACKGROUND

The txt2stop trial has shown that mobile-phone-based smoking cessation support doubles biochemically validated quitting at 6 months. This study examines the cost-effectiveness of smoking cessation support delivered by mobile phone text messaging.

METHODS

The lifetime incremental costs and benefits of adding text-based support to current practice are estimated from a UK NHS perspective using a Markov model. The cost-effectiveness was measured in terms of cost per quitter, cost per life year gained and cost per QALY gained. As in previous studies, smokers are assumed to face a higher risk of experiencing the following five diseases: lung cancer, stroke, myocardial infarction, chronic obstructive pulmonary disease, and coronary heart disease (i.e. the main fatal or disabling, but by no means the only, adverse effects of prolonged smoking). The treatment costs and health state values associated with these diseases were identified from the literature. The analysis was based on the age and gender distribution observed in the txt2stop trial. Effectiveness and cost parameters were varied in deterministic sensitivity analyses, and a probabilistic sensitivity analysis was also performed.

FINDINGS

The cost of text-based support per 1,000 enrolled smokers is £16,120, which, given an estimated 58 additional quitters at 6 months, equates to £278 per quitter. However, when the future NHS costs saved (as a result of reduced smoking) are included, text-based support would be cost saving. It is estimated that 18 LYs are gained per 1,000 smokers (0.3 LYs per quitter) receiving text-based support, and 29 QALYs are gained (0.5 QALYs per quitter). The deterministic sensitivity analysis indicated that changes in individual model parameters did not alter the conclusion that this is a cost-effective intervention. Similarly, the probabilistic sensitivity analysis indicated a >90 % chance that the intervention will be cost saving.

INTERPRETATION

This study shows that under a wide variety of conditions, personalised smoking cessation advice and support by mobile phone message is both beneficial for health and cost saving to a health system.

摘要

背景

txt2stop 试验表明,基于手机的戒烟支持将使 6 个月内生物化学验证的戒烟率提高一倍。本研究探讨了通过手机短信提供戒烟支持的成本效益。

方法

从英国国民保健制度的角度,使用马尔可夫模型,估算了在当前实践中增加基于文本的支持的终身增量成本和收益。成本效益以每戒烟者成本、每获得生命年成本和每获得 QALY 成本来衡量。与之前的研究一样,假设吸烟者面临更高的风险患上以下五种疾病:肺癌、中风、心肌梗死、慢性阻塞性肺疾病和冠心病(即长期吸烟的主要致命或致残,但绝非唯一的不良影响)。从文献中确定了与这些疾病相关的治疗成本和健康状况值。分析基于 txt2stop 试验中观察到的年龄和性别分布。在确定性敏感性分析中,对有效性和成本参数进行了调整,并进行了概率敏感性分析。

结果

每 1000 名入组吸烟者的基于文本的支持成本为 16120 英镑,考虑到 6 个月时预计有 58 名额外戒烟者,这相当于每个戒烟者 278 英镑。然而,当纳入未来 NHS 节省的成本(由于吸烟减少)时,基于文本的支持将具有成本效益。据估计,每 1000 名接受基于文本的支持的吸烟者获得 18 个生命年(每个戒烟者获得 0.3 个生命年),并获得 29 个 QALY(每个戒烟者获得 0.5 个 QALY)。确定性敏感性分析表明,个别模型参数的变化不会改变这是一种具有成本效益的干预措施的结论。同样,概率敏感性分析表明,该干预措施具有超过 90%的可能性是具有成本效益的。

解释

本研究表明,在各种条件下,通过手机短信提供个性化的戒烟建议和支持,既有益于健康,又能为医疗系统节省成本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e0/3751449/758f4414cad1/10198_2012_424_Fig1_HTML.jpg

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