Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China.
Histopathology. 2012 Dec;61(6):1219-24. doi: 10.1111/j.1365-2559.2012.04347.x. Epub 2012 Sep 11.
Pseudomyogenic haemangioendothelioma is a recently described vascular neoplasm that occurs most commonly in the soft tissue of distal extremities of young adults. Occurrence outside the somatic soft tissue has not been described thus far. We present here a unique case of pseudomyogenic haemangioendothelioma that arose in the long tubular bones of the lower extremity.
The initial open biopsy was interpreted as a fibrous histiocytoma. However, the curettage specimen showed prominent epithelioid cytomorphology with a striking rhabdomyoblast-like appearance. By immunohistochemistry, the linear membranous staining of CD31 was highly suggestive of endothelial differentiation of the tumour cells.
To the best of our knowledge, this case represents the first example of primary pseudomyogenic haemangioendothelioma of bone. Clinical and pathological correlation with application of immunohistochemistry is mandatory in establishing the correct diagnosis and excluding tumours with overlapping features.
假肌源性血管内皮瘤是一种新近描述的血管肿瘤，最常发生于年轻成人四肢远端的软组织中。迄今为止，尚未有发生于体腔外软组织的报道。我们在此报告一例独特的发生于下肢长管状骨的假肌源性血管内皮瘤。
初次开放性活检诊断为纤维组织细胞瘤。然而，刮除标本显示出明显的上皮样细胞形态，具有显著的横纹肌母细胞样外观。免疫组化显示 CD31 的线性膜染色强烈提示肿瘤细胞的内皮分化。
据我们所知，该病例代表了首例原发于骨的假肌源性血管内皮瘤。为了做出正确的诊断并排除具有重叠特征的肿瘤，必须进行临床和病理相关性研究，并应用免疫组化。
Zotero 插件