Ciaccia Maria Célia Cunha, Moreira Regina Célia, Ferraro Alexandre Archanjo, Lemos Marcílio Figueiredo, Oba Isabel Takano, Porta Gilda
Department of Pediatrics, Instituto da Criança, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Sao Paulo Med J. 2012;130(4):230-5. doi: 10.1590/s1516-31802012000400005.
Viral hepatitis A is still a concern at public health level in Brazil and around the world, due both to the number of affected subjects and the possibility of complications in the acute forms. The Brazilian Ministry of Health estimates that at least 70% of this country's population has already had contact with the hepatitis A virus (HAV). The aim here was to discover the prevalence of serological markers for the hepatitis A virus among children and teenagers at daycare facilities, kindergartens and elementary schools in the city of Santos.
Cross-sectional study in kindergartens and elementary schools within the municipal education network in several regions of the city of Santos.
Students' family members were surveyed using a questionnaire and 4,680 finger-prick blood samples were taken and assayed by means of the ELISA technique.
The general prevalence of anti-HAV IgG was 9.72% and, of these cases, 74.6% were reactive to anti-HAV IgM. There was higher prevalence of anti-HAV IgG among older children, females, children who played in streams, those whose homes were not connected to the sewage system, those whose parents had low education levels, those with low household income and those who did not live along the seashore. The prevalence of anti-HAV IgM peaked in the early years and subsequently fell, and it was lower on the hills and in the Northwestern Zone.
The general prevalence of serological markers for hepatitis A was low in Santos.
由于甲型病毒性肝炎的患病人数以及急性感染时出现并发症的可能性,在巴西乃至全球,甲型病毒性肝炎仍然是一个公共卫生问题。巴西卫生部估计,该国至少70%的人口已经接触过甲型肝炎病毒(HAV)。本研究旨在了解桑托斯市日托中心、幼儿园和小学的儿童及青少年中甲型肝炎病毒血清学标志物的流行情况。
在桑托斯市多个区域的市立教育网络内的幼儿园和小学进行横断面研究。
通过问卷调查对学生家庭成员进行调查,并采集4680份手指刺血样本,采用酶联免疫吸附测定(ELISA)技术进行检测。
抗-HAV IgG的总体流行率为9.72%,其中74.6%的病例抗-HAV IgM呈阳性反应。年龄较大的儿童、女性、在溪流中玩耍的儿童、家庭未接入污水系统的儿童、父母教育程度较低的儿童、家庭收入较低的儿童以及不住在沿海地区的儿童中抗-HAV IgG的流行率较高。抗-HAV IgM的流行率在早年达到峰值,随后下降,在山区和西北区较低。
桑托斯市甲型肝炎血清学标志物的总体流行率较低。