COUP-TFII 在癌症发生和进展中的多重作用。
Multiple roles of COUP-TFII in cancer initiation and progression.
机构信息
Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.
出版信息
J Mol Endocrinol. 2012 Oct 10;49(3):R135-48. doi: 10.1530/JME-12-0144. Print 2012 Dec.
Abstract
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is an orphan nuclear receptor that acts as a transcriptional activator or repressor in a cell type-dependent manner. Best characterized for its role in the regulation of angiogenesis during mouse development, COUP-TFII also plays important roles in glucose metabolism and cancer. Expression of COUP-TFII is altered in various endocrine conditions. Cell type-specific functions and the regulation of COUP-TFII expression result in its varying physiological and pathological actions in diverse systems. Evidence will be reviewed for oncogenic and tumor-suppressive functions of COUP-TFII, with roles in angiogenesis, metastasis, steroidogenesis, and endocrine sensitivity of breast cancer described. The applicability of current data to our understanding of the role of COUP-TFII in cancer will be discussed.
摘要
鸡卵清蛋白上游启动子转录因子 II（COUP-TFII）是一种孤儿核受体，以依赖于细胞类型的方式作为转录激活剂或抑制剂发挥作用。COUP-TFII 在调节小鼠发育过程中的血管生成方面的作用最为突出，它在葡萄糖代谢和癌症中也发挥着重要作用。在各种内分泌条件下，COUP-TFII 的表达发生改变。COUP-TFII 的细胞类型特异性功能和表达的调节导致其在不同系统中具有不同的生理和病理作用。将对 COUP-TFII 的致癌和肿瘤抑制功能进行综述，描述其在血管生成、转移、类固醇生成以及乳腺癌的内分泌敏感性中的作用。将讨论当前数据对我们理解 COUP-TFII 在癌症中的作用的适用性。
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