Nambu Hiroyuki, Jo Nobuo, Kuro Maki, Minamino Keizo, Ando Akira, Nambu Rie, Matsumura Miyo, Takahashi Kanji
Department of Ophthalmology, Kansai Medical University Hirakata Hospital, Japan.
Nippon Ganka Gakkai Zasshi. 2012 Aug;116(8):740-50.
To evaluate retrospectively the long-term effects of initial trabeculotomy combined with sinusotomy performed inferiorly.
Enrolled were 128 eyes of 100 patients who received initial glaucoma surgery. In 36 eyes, the removal of Schlemm's canal endothelium was also performed (removed group). The results were compared with the intact group
In the primary open angle glaucoma (POAG), mean intraocular pressure (IOP) at 3 years after surgery was 14.6 (intact) and 15.4 mmHg (removed). Kaplan-Meier life-table analysis showed that qualified success rates for the intact group at 8 years were 62.2% and for the removed group at 5 years 45.2% defined by 20 mmHg or lower. The results in developmental glaucoma (DG) were similar to those in POAG. No statistical differences in postoperative IOP between the intact and removed groups were seen in either POAG or DG. In exfoliation glaucoma (XFG), mean IOPs for the intact group at 3 years were 17.3 mmHg and for the removed group at 2 years 15.4 mmHg. The success rates for the intact group at 3.5 years were 25.2% and for the removed group at 4.5 years 64.3%. The results in the intact group were worse than in the POAG patients. Although visual disturbance was seen in 13% of the patients, the major cause was the progression of the cataracts.
The long-term results were the same as those of previous reports on surgery performed superiorly, including the frequency of visual disturbance. However the removal of Schlemm's canal endothelium is necessary in XFG for better IOP control.
回顾性评估初次小梁切开术联合下方鼻窦切开术的长期效果。
纳入100例接受初次青光眼手术的患者的128只眼。其中36只眼还进行了施莱姆管内皮切除术(切除组)。将结果与完整组进行比较。
在原发性开角型青光眼(POAG)中,术后3年的平均眼压(IOP),完整组为14.6 mmHg,切除组为15.4 mmHg。Kaplan-Meier生存表分析显示,完整组8年时眼压合格成功率为62.2%,切除组5年时为45.2%(定义为眼压20 mmHg或更低)。发育性青光眼(DG)的结果与POAG相似。在POAG或DG中,完整组和切除组术后眼压均无统计学差异。在剥脱性青光眼(XFG)中,完整组3年时的平均眼压为17.3 mmHg,切除组2年时为15.4 mmHg。完整组3.5年时的成功率为25.2%,切除组4.5年时为64.3%。完整组的结果比POAG患者差。虽然13%的患者出现视力障碍,但主要原因是白内障进展。
长期结果与先前关于上方手术的报道相同,包括视力障碍的发生率。然而,在XFG中,为了更好地控制眼压,施莱姆管内皮切除术是必要的。