秀丽隐杆线虫中的神经再生。
Neural regeneration in Caenorhabditis elegans.
机构信息
Department of Genetics, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University, New Haven, Connecticut 06510, USA.
出版信息
Annu Rev Genet. 2012;46:499-513. doi: 10.1146/annurev-genet-110711-155550. Epub 2012 Sep 4.
Abstract
Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C. elegans as a tool to leverage discovery is a legitimate strategy for identifying conserved mechanisms of axon regeneration.
摘要
轴突再生是一种与医学相关的过程，可以修复受损的神经元。这篇综述描述了在模式生物秀丽隐杆线虫中对轴突再生的理解的当前进展。调节秀丽隐杆线虫轴突再生的因素在脊椎动物神经元中具有广泛相似的作用。这意味着，将秀丽隐杆线虫作为一种利用发现的工具是一种识别轴突再生保守机制的合理策略。
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