IDH1 突变破坏血液、大脑和屏障。
IDH1 mutations disrupt blood, brain, and barriers.
机构信息
Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Cancer Cell. 2012 Sep 11;22(3):285-7. doi: 10.1016/j.ccr.2012.08.022.
PMID:22975371
Abstract
The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collagen and prolyl hydroxylases lead to altered microenvironment and defective angiogenesis.
摘要
前两个 IDH1(R132H)突变的鼠模型为转化提供了机制上的见解。在造血细胞中，TET2 和组蛋白去甲基酶的抑制导致表观遗传改变和造血前体细胞的积累。在中枢神经系统中，胶原和脯氨酰羟化酶的抑制导致微环境改变和血管生成缺陷。
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