孕期循环 25-羟维生素 D3 与婴儿神经心理发育。

Circulating 25-hydroxyvitamin D3 in pregnancy and infant neuropsychological development.

机构信息

Centre for Research in Environmental Epidemiology (CREAL), Parc de Recerca Biomèdica de Barcelona, Dr Aiguader 88, 08003-Barcelona, Catalonia, Spain.

出版信息

Pediatrics. 2012 Oct;130(4):e913-20. doi: 10.1542/peds.2011-3289. Epub 2012 Sep 17.

DOI:10.1542/peds.2011-3289

PMID:22987876

Abstract

OBJECTIVE

To investigate whether circulating 25-hydroxyvitamin D(3) [25(OH)D(3)] concentration in pregnancy is associated with neuropsychological development in infants.

METHODS

The Spanish population-based cohort study INfancia y Medio Ambiente Project recruited pregnant women during the first trimester of pregnancy between November 2003 and February 2008. Completed data on 1820 mother-infant pairs were used. Maternal plasma 25(OH)D(3) concentration was measured by high-performance liquid chromatography in pregnancy (mean 13.5 ± 2.1 weeks of gestation). Offspring mental and psychomotor scores were assessed by trained psychologists at age 14 months (range, 11-23) by using the Bayley Scales of Infant Development. β-Coefficients with 95% confidence intervals (CIs) of mental and psychomotor scores associated with continuous or categorical concentrations of maternal plasma 25(OH)D(3) were calculated by using linear regression analysis.

RESULTS

The median plasma value of 25(OH)D(3) in pregnancy was 29.6 ng/mL (interquartile range, 21.8-37.3). A positive linear relationship was found between circulating concentrations of maternal 25(OH)D(3) concentrations in pregnancy and mental and psychomotor scores in the offspring. After adjustment for potential confounders, infants of mothers with 25(OH)D(3) concentrations in pregnancy >30 ng/mL showed higher mental score (β = 2.60; 95% CI 0.63-4.56) and higher psychomotor score (β = 2.32; 95% CI 0.36-4.28) in comparison with those of mothers with 25(OH)D(3) concentrations <20 ng/mL.

CONCLUSIONS

Higher circulating concentration of maternal 25(OH)D(3) in pregnancy was associated with improved mental and psychomotor development in infants.

摘要

目的

探讨孕妇循环中 25-羟维生素 D（3）[25（OH）D（3）]浓度是否与婴儿的神经心理发育有关。

方法

这项基于西班牙人群的队列研究 INfancia y Medio Ambiente 项目于 2003 年 11 月至 2008 年 2 月在妊娠早期招募了孕妇。使用了 1820 对母婴完成的数据。在妊娠期间（平均妊娠 13.5±2.1 周）通过高效液相色谱法测量母体血浆 25（OH）D（3）浓度。在 14 个月龄（范围 11-23 个月）时，由经过培训的心理学家使用贝利婴幼儿发育量表评估后代的心理和运动评分。通过线性回归分析计算与母体血浆 25（OH）D（3）连续或分类浓度相关的心理和运动评分的β系数及其 95%置信区间（CI）。

结果

妊娠期间的中位血浆 25（OH）D（3）值为 29.6ng/mL（四分位距，21.8-37.3）。在妊娠期间母体 25（OH）D（3）浓度与后代的心理和运动评分之间存在正线性关系。在校正潜在混杂因素后，与 25（OH）D（3）浓度<20ng/mL 的母亲的婴儿相比，25（OH）D（3）浓度>30ng/mL 的母亲的婴儿的心理评分更高（β=2.60；95%CI 0.63-4.56）和运动评分更高（β=2.32；95%CI 0.36-4.28）。