介孔硅纳米粒子表面配位聚合物用于 pH 响应性药物释放。
Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release.
机构信息
School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
出版信息
Adv Mater. 2012 Dec 18;24(48):6433-7. doi: 10.1002/adma.201201742. Epub 2012 Sep 24.
Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H(+) stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.
成功合成了用于药物输送的配位聚合物包覆的介孔硅纳米粒子。该系统确保药物在生理环境下储存在介孔中。在内涵体和溶酶体隔室内的 H(+)刺激下，药物被释放到癌细胞的细胞内细胞器中，从而有效地杀死细胞。
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