外周血淋巴细胞中的丝裂原受体与对丝裂原的增殖反应之间的关系。
Relationship between mitogen receptors in peripheral blood lymphocytes and blastogenic responses to mitogen.
作者信息
Tajima M, Fujinaga T, Okamoto Y, Otomo K, Koike T
机构信息
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
出版信息
Res Vet Sci. 1990 Jan;48(1):1-5.
The relationship between the optimum concentration of mitogen which induces lymphocyte blastogenic response and the receptor occupancy by mitogen was investigated. The receptor occupancies which induced maximal blastogenic activity in equine, bovine and canine peripheral blood lymphocytes (PBL) were 31.1 per cent, 26.5 per cent and 38.4 per cent with phytohaemagglutinin-P, and 48.2 per cent, 17.9 per cent and 24.5 per cent with concanavalin A, respectively. The data clearly show that each animal species had its own optimum concentration of mitogen for stimulation of PBL. Optimum concentration for blastogenesis and number of binding sites of each mitogen had a good correlation with each other for all three species.
研究了诱导淋巴细胞增殖反应的丝裂原最佳浓度与丝裂原受体占有率之间的关系。用植物血凝素-P诱导马、牛和犬外周血淋巴细胞（PBL）产生最大增殖活性时的受体占有率分别为31.1%、26.5%和38.4%，用刀豆球蛋白A诱导时分别为48.2%、17.9%和24.5%。数据清楚地表明，每种动物物种都有其刺激PBL的丝裂原最佳浓度。对于所有三个物种，丝裂原的增殖最佳浓度与其结合位点数量之间都具有良好的相关性。
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