Rodrigues L, Neves M, Machado S, Sá H, Macário F, Alves R, Mota A, Campos M
Department of Nephrology, Hospitais da Universidade de Coimbra, Coimbra, Portugal.
Transplant Proc. 2012 Oct;44(8):2507-9. doi: 10.1016/j.transproceed.2012.07.014.
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of end-stage renal disease (ESRD) and, because of its intrinsic systemic involvement, its treatment can be a medical and surgical challenge. This condition is often associated with the presence of hepatic cysts and their prevalence generally increases with age. Most patients remain asymptomatic, but some of these will develop complications associated with enlargement and infection of their cysts. Chest pain is a rare manifestation of these complications and, after exclusion of more common cardiovascular and pulmonary causes, should raise the suspicion of an infected hepatic cyst in these patients. We report the case of a 62-year-old male who underwent a kidney transplantation from a cadaveric donor in 1997 (etiology of the ESRD was ADPKD), and was admitted to the emergency department with complaints of chest pain radiating to both shoulders and the interscapular region. An echocardiogram was showed compression of the right atrium by a large liver cyst without associated ventricular dysfunction. Computer tomography-guided drainage of the cyst was performed and an Enterobacter aerogenes sensitive to carbamapenemes was isolated from respective cultures. The patient presented a favorable clinical outcome with prolonged administration of antibiotic therapy according to the antibiotic susceptibility testing. There was no need for surgical intervention.
常染色体显性多囊肾病(ADPKD)是终末期肾病(ESRD)的常见病因,由于其内在的全身受累情况,其治疗可能是医学和外科方面的挑战。这种疾病常伴有肝囊肿,其患病率通常随年龄增长而增加。大多数患者无症状,但其中一些会出现与囊肿增大和感染相关的并发症。胸痛是这些并发症的罕见表现,在排除更常见的心血管和肺部病因后,应怀疑这些患者存在感染性肝囊肿。我们报告一例62岁男性病例,该患者于1997年接受了来自尸体供体的肾移植(ESRD的病因是ADPKD),因胸痛放射至双肩和肩胛间区域而入住急诊科。超声心动图显示一个大的肝囊肿压迫右心房,无相关心室功能障碍。在计算机断层扫描引导下对囊肿进行了引流,并从相应培养物中分离出对碳青霉烯类敏感的产气肠杆菌。根据抗生素敏感性试验,患者通过长期使用抗生素治疗获得了良好的临床结果。无需手术干预。