1994年至2004年期间对90名尼日利亚非洲裔前列腺癌患者的Gleason分级和评分分析。
Analysis of Gleason grade and scores in 90 Nigerian Africans with prostate cancer during the period 1994 to 2004.
作者信息
Ugare U G, Bassey I E, Jibrin P G, Ekanem I A
机构信息
Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria.
出版信息
Afr Health Sci. 2012 Mar;12(1):69-73.
OBJECTIVES
To determine the relative frequency of prostate cancer among surgical specimens, and among prostate specimens received at the pathology department ,University Hospital Calabar.
METHODS
Histology records were reviewed for the following: total number of histology specimens received; total number of prostate specimens; total number of prostate cancer; and the total number of cancers in males during the study period. Histology sections 4-5microns thick were cut from paraffin blocks and stained by Haematoxylin and Eosin (H&E). Histopathologic specimens were classified using the grading system of tumour differentiation described by Gleason and associates.
RESULTS
One hundred and twenty three cancers of the prostate were received, constituting 2% of the total surgical specimens and 31% of prostate specimens. Thirty three cases (27%) could not be analyzed; therefore the study is based on 90 prostate cancer specimens. Eighty nine (99%) cases were epithelial tumours (adenocarcinoma.) There was a single mesenchymal tumour (rhabdomyosarcoma) (1%). The commonest grade in this study was the high grade (Gleason grade IV).
CONCLUSIONS
We observed that prostate cancer is a common among males (all sites) diagnosed at the University Hospital Calabar, with a peak incidence between the ages of 61 - 70 years (seventh decade).
目的
确定在外科手术标本以及卡拉巴尔大学医院病理科接收的前列腺标本中前列腺癌的相对发生率。
方法
回顾组织学记录，内容如下：接收的组织学标本总数；前列腺标本总数；前列腺癌总数；以及研究期间男性癌症总数。从石蜡块上切取4 - 5微米厚的组织学切片，并用苏木精和伊红（H&E）染色。组织病理学标本采用Gleason及其同事描述的肿瘤分化分级系统进行分类。
结果
共接收123例前列腺癌，占手术标本总数的2%，前列腺标本总数的31%。33例（27%）无法进行分析；因此本研究基于90例前列腺癌标本。89例（99%）为上皮性肿瘤（腺癌）。有1例间叶性肿瘤（横纹肌肉瘤）（1%）。本研究中最常见的分级为高级别（Gleason四级）。
结论
我们观察到前列腺癌在卡拉巴尔大学医院诊断的男性（所有部位）中较为常见，发病高峰在61 - 70岁（第七个十年）之间。
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