Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
Cancer Cell. 2012 Oct 16;22(4):421-2. doi: 10.1016/j.ccr.2012.09.018.
The childhood cancer embryonal rhabdomyosarcoma can arise in tissue without skeletal muscle elements. In this issue of Cancer Cell, Hatley and colleagues report that non-skeletal muscle progenitors can be a cell of origin for Sonic Hedgehog-driven embryonal rhabdomyosarcoma in an adipocyte-restricted conditional mouse model.
儿童癌症胚胎横纹肌肉瘤可发生在没有骨骼肌成分的组织中。在本期《癌细胞》杂志中,Hatley 及其同事报道,脂肪细胞受限条件性小鼠模型中,非骨骼肌祖细胞可作为 Sonic Hedgehog 驱动的胚胎横纹肌肉瘤的起始细胞。