孕激素对新生大鼠低氧通气反应的剂量依赖性影响。
Dose dependent effect of progesterone on hypoxic ventilatory response in newborn rats.
机构信息
Département de Pédiatrie, Université Laval, Québec, Canada.
出版信息
Adv Exp Med Biol. 2012;758:43-8. doi: 10.1007/978-94-007-4584-1_6.
The effect of progesterone as a respiratory stimulant in newborn subjects is less known than that in adults. This study investigated the dose-response curve (0, 2, 4, and 8 mg/kg, ip) of progesterone on ventilation in non-anesthetized newborn rats at 4- and 12-days old using plethysmography. Progesterone had no effects in the regulation of normoxic ventilation. However, it enhanced the response to moderate hypoxia (FiO(2) 12%, 20 min) in 4- but not in 12-days old pups. This response was similar between the dose of 4 and 8 mg/kg. These observations suggested that progesterone enhances in age- and dose-dependent manner the hypoxic ventilatory response in newborn rats.
孕激素作为一种呼吸兴奋剂，其在新生儿中的作用不如在成人中那么明显。本研究采用体描法，在 4 日龄和 12 日龄的未麻醉新生大鼠中，研究了孕激素（0、2、4 和 8 mg/kg，ip）对通气的剂量-反应曲线。孕激素对正常氧合通气无影响。然而，它增强了 4 日龄而非 12 日龄幼仔对中度低氧（FiO2 12%，20 分钟）的反应。4 mg/kg 和 8 mg/kg 之间的这种反应相似。这些观察结果表明，孕激素以年龄和剂量依赖的方式增强新生大鼠的低氧通气反应。
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