本地治里女性的甲状腺疾病
Thyroid disorders in women of Puducherry.
作者信息
Abraham Rebecca, Srinivasa Murugan V, Pukazhvanthen P, Sen S K
机构信息
Department of Biochemistry, Pondicherry Institute of Medical Sciences, Puducherry, 605014 India.
出版信息
Indian J Clin Biochem. 2009 Jan;24(1):52-9. doi: 10.1007/s12291-009-0009-y. Epub 2009 May 8.
Thyroid stimulating hormone (TSH), Free Thyroxine (FT(4)) and Free Triiodothyronine (FT(3)) were assayed in 505 women of this region. 60 women had previous history of thyroid disease. The remaining 445 women formed the "Disease free group". A "Reference group" was obtained by excluding women with previous and present history of thyroid dysfunction. Of the total 505 women examined 15.8% had thyroid dysfunction and 84.2% were euthyroid. 11.5% were hypothyroid (9.5% sub-clinical) and 1.8% hyperthyroid (1.2% clinical). The geometric mean TSH for the total population was 2.65 μIU/ml. It was significantly (p=0.025) lower in the reference population 2.17 μIU/ml. There was no significant difference in the FT(3) and FT(4) values between groups. 19% of women over 60 years had elevated TSH above 4.5 μIU/ml. The 2.5 and 97.5 percentiles of the reference population was 1.1-5.2 μIU/ml. 6.1% of women in the reference group had TSH levels above the reference intervals. Hypothyroidism particularly sub-clinical hypothyroidism is predominantly present amongst women in this iodine sufficient region. Evaluation of thyroid status could help in early detection and treatment.
对该地区的505名女性进行了促甲状腺激素（TSH）、游离甲状腺素（FT4）和游离三碘甲状腺原氨酸（FT3）检测。60名女性有甲状腺疾病病史。其余445名女性组成“无疾病组”。通过排除有既往和当前甲状腺功能障碍病史的女性获得“参考组”。在接受检查的505名女性中，15.8%有甲状腺功能障碍，84.2%甲状腺功能正常。11.5%为甲状腺功能减退（9.5%为亚临床型），1.8%为甲状腺功能亢进（1.2%为临床型）。总体人群的促甲状腺激素几何平均值为2.65μIU/ml。参考人群中的该值显著较低（p = 0.025），为2.17μIU/ml。各组之间的FT3和FT4值无显著差异。60岁以上女性中有19%的促甲状腺激素升高至4.5μIU/ml以上。参考人群的第2.5和第97.5百分位数为1.1 - 5.2μIU/ml。参考组中有6.1%的女性促甲状腺激素水平高于参考区间。在这个碘充足地区的女性中，甲状腺功能减退尤其是亚临床甲状腺功能减退较为普遍。评估甲状腺状态有助于早期发现和治疗。
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