染色质重编程障碍：50 年的探索之路。

Chromatin roadblocks to reprogramming 50 years on.

机构信息

Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

出版信息

BMC Biol. 2012 Oct 29;10:83. doi: 10.1186/1741-7007-10-83.

DOI:10.1186/1741-7007-10-83

PMID:23107587

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3483161/

Abstract

A half century after John Gurdon demonstrated nuclear reprogramming, for which he was awarded the 2012 Nobel Prize in Physiology or Medicine, his group provides insights into the molecular mechanisms whereby chromatin remodeling is required for nuclear reprogramming. Among the issues addressed in Gurdon's latest work are the chromatin impediments to artificially induced reprogramming, discovered by Shinya Yamanaka, who shared the award with Gurdon.

摘要

在 John Gurdon 展示核重编程半个世纪之后，他因这项工作获得了 2012 年诺贝尔生理学或医学奖。他的团队深入研究了染色质重塑在核重编程中所必需的分子机制。Gurdon 最新的研究工作解决了一些问题，这些问题是由 Shinya Yamanaka 发现的，他与 Gurdon 共同分享了该奖项，其中包括人工诱导重编程中染色质障碍。