对乙酰氨基酚的正确使用。
The proper use of acetaminophen.
作者信息
James Laura, Sullivan Janice E, Roberts Dean
机构信息
Department of Pediatrics, University of Arkansas for Medical Sciences, Section of Clinical Pharmacology and Toxicology, Arkansas Children's Hospital, Little Rock, Arkansas;
出版信息
Paediatr Child Health. 2011 Nov;16(9):544-7. doi: 10.1093/pch/16.9.544.
Abstract
Acetaminophen (N-acetyl-p-aminophenol, paracetamol [APAP])-induced acute liver failure is the most common cause of acute liver failure in adults. In children, APAP accounts for 25% of all cases of acute liver failure. The high mortality rate associated with this preventable condition makes it vital that paediatricians are aware of the potential adverse effects associated with this widely used drug. While APAP is generally considered to be safe when used as directed, its inclusion in multiple over-the-counter medications, as well as in prescription drugs, mandates that physicians promote and educate the general public about the proper use of acetaminophen in children.
摘要
对乙酰氨基酚（N-乙酰对氨基酚，扑热息痛[APAP]）所致急性肝衰竭是成人急性肝衰竭最常见的病因。在儿童中，APAP占急性肝衰竭所有病例的25%。这种可预防疾病所伴随的高死亡率使得儿科医生意识到这种广泛使用药物的潜在不良反应至关重要。虽然按指示使用时APAP一般被认为是安全的，但它被包含在多种非处方药以及处方药中，这就要求医生向公众宣传并教育如何正确给儿童使用对乙酰氨基酚。
相似文献
1
The proper use of acetaminophen.
Paediatr Child Health. 2011 Nov;16(9):544-7. doi: 10.1093/pch/16.9.544.
2
Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and Acute Liver Failure.
Clin Liver Dis. 2018 May;22(2):325-346. doi: 10.1016/j.cld.2018.01.007. Epub 2018 Feb 9.
3
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Drug Metab Dispos. 2009 Aug;37(8):1779-84. doi: 10.1124/dmd.108.026195. Epub 2009 May 13.
4
Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury.
Int J Mol Sci. 2018 Nov 28;19(12):3776. doi: 10.3390/ijms19123776.
5
Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?
Biol Pharm Bull. 2020;43(2):195-206. doi: 10.1248/bpb.b19-00722.
6
The therapeutic applications of and risks associated with acetaminophen use: a review and update.
J Am Dent Assoc. 2011 Jan;142(1):38-44. doi: 10.14219/jada.archive.2011.0026.
7
N-acetylcysteine amide, a promising antidote for acetaminophen toxicity.
Toxicol Lett. 2016 Jan 22;241:133-42. doi: 10.1016/j.toxlet.2015.11.008. Epub 2015 Nov 19.
8
Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.
Toxicol Sci. 2020 May 1;175(1):87-97. doi: 10.1093/toxsci/kfaa023.
9
Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes.
Biochem Pharmacol. 1991 Aug 8;42(5):1137-42. doi: 10.1016/0006-2952(91)90299-k.
10
Meat tenderization using acetaminophen (paracetamol/APAP): A review on deductive biochemical mechanisms, toxicological implications and strategies for mitigation.
Heliyon. 2023 Apr 21;9(5):e15628. doi: 10.1016/j.heliyon.2023.e15628. eCollection 2023 May.
引用本文的文献
1
Drug-Induced Liver Injury-Pharmacological Spectrum Among Children.
Int J Mol Sci. 2025 Feb 25;26(5):2006. doi: 10.3390/ijms26052006.
2
The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits.
Children (Basel). 2023 Dec 29;11(1):44. doi: 10.3390/children11010044.
3
Hepatic, Extrahepatic and Extracellular Vesicle Cytochrome P450 2E1 in Alcohol and Acetaminophen-Mediated Adverse Interactions and Potential Treatment Options.
Cells. 2022 Aug 23;11(17):2620. doi: 10.3390/cells11172620.
4
Hypergravity Load Modulates Acetaminophen Nephrotoxicity via Endoplasmic Reticulum Stress in Association with Hepatic microRNA-122 Expression.
Int J Mol Sci. 2021 May 5;22(9):4901. doi: 10.3390/ijms22094901.
5
Reducing Time to Pain Medication Administration for Pediatric Patients with Long Bone Fractures in the Emergency Department.
Pediatr Qual Saf. 2018 Nov 15;3(6):e120. doi: 10.1097/pq9.0000000000000120. eCollection 2018 Nov-Dec.
6
Acetaminophen administration in pediatric age: an observational prospective cross-sectional study.
Ital J Pediatr. 2016 Feb 26;42:20. doi: 10.1186/s13052-016-0219-x.
7
Approaches to the Development of Human Health Toxicity Values for Active Pharmaceutical Ingredients in the Environment.
AAPS J. 2016 Jan;18(1):92-101. doi: 10.1208/s12248-015-9818-5. Epub 2015 Sep 3.
8
Can medical students identify a potentially serious acetaminophen dosing error in a simulated encounter? a case control study.
BMC Med Educ. 2015 Feb 11;15:13. doi: 10.1186/s12909-015-0288-3.
9
Pediatric pain management: a review.
Mo Med. 2014 May-Jun;111(3):231-7.
本文引用的文献
1
Fever and antipyretic use in children.
Pediatrics. 2011 Mar;127(3):580-7. doi: 10.1542/peds.2010-3852. Epub 2011 Feb 28.
2
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Hepatology. 2011 Feb;53(2):567-76. doi: 10.1002/hep.24060. Epub 2011 Jan 10.
3
Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.
Toxicol Sci. 2011 Mar;120(1):33-41. doi: 10.1093/toxsci/kfq375. Epub 2010 Dec 22.
4
Therapeutic acetaminophen is not associated with liver injury in children: a systematic review.
Pediatrics. 2010 Dec;126(6):e1430-44. doi: 10.1542/peds.2009-3352. Epub 2010 Nov 22.
5
Mechanisms of acetaminophen-induced liver necrosis.
Handb Exp Pharmacol. 2010(196):369-405. doi: 10.1007/978-3-642-00663-0_12.
6
A difficult balance--pain management, drug safety, and the FDA.
N Engl J Med. 2009 Nov 26;361(22):2105-7. doi: 10.1056/NEJMp0908913.
7
Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.
Hepatology. 2010 Jan;51(1):227-36. doi: 10.1002/hep.23330.
8
Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning.
Ann Emerg Med. 2009 Oct;54(4):606-14. doi: 10.1016/j.annemergmed.2009.05.010. Epub 2009 Jun 25.
9
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Drug Metab Dispos. 2009 Aug;37(8):1779-84. doi: 10.1124/dmd.108.026195. Epub 2009 May 13.
10
Acetylcysteine for acetaminophen poisoning.
N Engl J Med. 2008 Jul 17;359(3):285-92. doi: 10.1056/NEJMct0708278.
Zotero 插件