莲（Nelumbo nucifera）胚生物碱的合成与药理活性
Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera.
作者信息
Nishimura Katsumi, Horii Shinji, Tanahashi Takao, Sugimoto Yumi, Yamada Jun
机构信息
Kobe Pharmaceutical University, Kobe 658-8558, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2013;61(1):59-68. doi: 10.1248/cpb.c12-00820. Epub 2012 Oct 29.
PMID:23117579
Abstract
Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity of nelumboferine, stereoisomers of neferine, liensinine, isoliensinine, and O-methylneferine were evaluated.
摘要
双苄基异喹啉生物碱、最近从莲的胚中分离出的莲房碱，以及莲心碱（莲的胚中的一种主要生物碱）的立体异构体被立体选择性合成。对莲房碱、莲心碱的立体异构体、莲碱、异莲碱和O-甲基莲心碱的药理活性进行了评估。
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