盐酸异美铵对大鼠伊氏锥虫感染的影响。
Effect of isometamidium hydrochloride on Trypanosoma evansi infections in rats.
作者信息
Kumar Upendra, Jas Ruma, Ghosh J D
机构信息
Department of Veterinary Parasitology, West Bengal University of Animal & Fishery Sciences, Belgachia, Kolkata, 700037 India.
出版信息
J Parasit Dis. 2009 Dec;33(1-2):36-41. doi: 10.1007/s12639-009-0006-3. Epub 2010 Feb 27.
Effect of Isometamidium treatment of rats infected with Trypanosoma evansi was studied under experimental condition. The infection resulted in 100 per cent mortality by 7 day post treatment (DPT) in the infected untreated rats (Gr.II) and Isometamidium-HCl exerted 90 percent anti-trypanosomal efficacy. Haematological studies of all the groups on 3 day post infection (DPI) and on 7 DPT showed that T. evansi infection significantly decreased haematological values, however Isometamidium treatment significantly (P < 0.05) improved Hb and PCV without any significant changes in TEC and TLC values. Serum AST and ALT activities were significantly (P < 0.01) higher in the treated rats compared to healthy rats. Treatment with Isometamidium-HCl significantly improved blood glucose level but decreased creatinine level compared to pretreatment values. There was no significant change in BUN level of treated rats but the value was higher (P < 0.01) compared to healthy rats.
在实验条件下研究了异美啶治疗感染伊氏锥虫大鼠的效果。感染导致未治疗的感染大鼠（第二组）在治疗后7天（DPT）的死亡率为100%，盐酸异美啶具有90%的抗锥虫功效。对感染后3天（DPI）和治疗后7天所有组的血液学研究表明，伊氏锥虫感染显著降低了血液学值，然而异美啶治疗显著（P<0.05）提高了血红蛋白（Hb）和红细胞压积（PCV），而红细胞计数（TEC）和白细胞计数（TLC）值没有任何显著变化。与健康大鼠相比，治疗大鼠的血清谷草转氨酶（AST）和谷丙转氨酶（ALT）活性显著（P<0.01）更高。与预处理值相比，盐酸异美啶治疗显著提高了血糖水平，但降低了肌酐水平。治疗大鼠的尿素氮（BUN）水平没有显著变化，但与健康大鼠相比该值更高（P<0.01）。
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