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黑猩猩和人类具有组成相似的肠道肠型。

Chimpanzees and humans harbour compositionally similar gut enterotypes.

机构信息

Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA.

出版信息

Nat Commun. 2012;3:1179. doi: 10.1038/ncomms2159.

Abstract

Microbes inhabiting the human gastrointestinal tract tend to adopt one of three characteristic community structures, called 'enterotypes', each of which is overrepresented by a distinct set of bacterial genera. Here we report that the gut microbiotae of chimpanzees also assort into enterotypes and that these chimpanzee enterotypes are compositionally analogous to those of humans. Through the analysis of longitudinal samples, we show that the microbial signatures of the enterotypes are stable over time, but that individual hosts switch between enterotypes over periods longer than a year. These results support the hypothesis that enterotypic variation was present in populations of great apes before the divergence of humans and chimpanzees.

摘要

人类胃肠道内栖息的微生物往往呈现出三种典型的群落结构,被称为“肠型”,每种肠型都由一组独特的细菌属过度代表。在这里,我们报告说,黑猩猩的肠道微生物组也可以分为肠型,并且这些黑猩猩肠型在组成上与人类肠型相似。通过对纵向样本的分析,我们表明,肠型的微生物特征是稳定的,但个体宿主在一年以上的时间内会在肠型之间转换。这些结果支持了这样一种假设,即在人类和黑猩猩分化之前,大型猿类种群中就存在肠型变异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/255c/3520023/28d012b87c6f/nihms425633f1.jpg

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