高官能化氟化顺式戊烷嘧啶衍生物的合成。
Synthesis of highly functionalized fluorinated cispentacin derivatives.
机构信息
Institute of Pharmaceutical Chemistry, University of Szeged, HU-6720, Eötvös 6, Hungary.
出版信息
Chem Biodivers. 2012 Nov;9(11):2571-81. doi: 10.1002/cbdv.201200323.
PMID:23161635
Abstract
Fluorinated highly functionalized cispentacin derivatives were synthetised starting from an unsaturated bicyclic β-lactam through C=C bond functionalization via the dipolar cycloaddition of a nitrile oxide, isoxazoline opening, and fluorination by OH/F exchange.
摘要
从不饱和双环β-内酰胺出发，通过 C=C 键官能团化，通过腈氧化物的偶极环加成、异恶唑啉开环和 OH/F 交换氟化，合成了氟化的高度官能化的 cis-戊二烯衍生物。
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