Department of Community Public Health, School of Nursing, Johns Hopkins University, 525 Wolfe St, Ste 316, Baltimore, MD 21205, USA.
JAMA. 2012 Nov 21;308(19):2020-9. doi: 10.1001/jama.2012.36918.
Behavioral symptoms such as repetitive speech, wandering, and sleep disturbances are a core clinical feature of Alzheimer disease and related dementias. If untreated, these behaviors can accelerate disease progression, worsen functional decline and quality of life, cause significant caregiver distress, and result in earlier nursing home placement. Systematic screening for behavioral symptoms in dementia is an important prevention strategy that facilitates early treatment of behavioral symptoms by identifying underlying causes and tailoring a treatment plan. First-line nonpharmacologic treatments are recommended because available pharmacologic treatments are only modestly effective, have notable risks, and do not effectively treat some of the behaviors that family members and caregivers find most distressing. Examples of nonpharmacologic treatments include provision of caregiver education and support, training in problem solving, and targeted therapy directed at the underlying causes for specific behaviors (eg, implementing nighttime routines to address sleep disturbances). Based on an actual case, we characterize common behavioral symptoms and describe a strategy for selecting evidence-based nonpharmacologic dementia treatments. Nonpharmacologic management of behavioral symptoms in dementia can significantly improve quality of life and patient-caregiver satisfaction.
行为症状,如重复言语、 wandered(这个单词可能是 wander 的过去分词形式)和睡眠障碍,是阿尔茨海默病和相关痴呆症的核心临床特征。如果不加治疗,这些行为会加速疾病进展,导致功能下降和生活质量恶化,给照料者带来严重的困扰,并导致更早地入住养老院。在痴呆症中系统性筛查行为症状是一项重要的预防策略,它可以通过识别潜在原因和制定治疗计划来促进早期治疗行为症状。推荐一线非药物治疗,因为现有的药物治疗效果有限,风险明显,并且不能有效治疗一些家庭成员和照料者最感到困扰的行为。非药物治疗的例子包括提供照料者教育和支持、解决问题的培训,以及针对特定行为的潜在原因的靶向治疗(例如,实施夜间常规以解决睡眠障碍)。基于一个实际案例,我们描述了常见的行为症状,并描述了选择基于证据的非药物痴呆症治疗的策略。痴呆症的行为症状的非药物管理可以显著提高生活质量和患者-照料者满意度。