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使用稳健推理系统准确远程监测帕金森病诊断。

Accurate telemonitoring of Parkinson's disease diagnosis using robust inference system.

机构信息

School of Computing, SASTRA University, Tamil Nadu 613401, India.

出版信息

Int J Med Inform. 2013 May;82(5):359-77. doi: 10.1016/j.ijmedinf.2012.10.006. Epub 2012 Nov 22.

Abstract

This work presents more precise computational methods for improving the diagnosis of Parkinson's disease based on the detection of dysphonia. New methods are presented for enhanced evaluation and recognize Parkinson's disease affected patients at early stage. Analysis is performed with significant level of error tolerance rate and established our results with corrected T-test. Here new ensembles and other machine learning methods consisting of multinomial logistic regression classifier with Haar wavelets transformation as projection filter that outperform logistic regression is used. Finally a novel and reliable inference system is presented for early recognition of people affected by this disease and presents a new measure of the severity of the disease. Feature selection method is based on Support Vector Machines and ranker search method. Performance analysis of each model is compared to the existing methods and examines the main advancements and concludes with propitious results. Reliable methods are proposed for treating Parkinson's disease that includes sparse multinomial logistic regression, Bayesian network, Support Vector Machines, Artificial Neural Networks, Boosting methods and their ensembles. The study aim at improving the quality of Parkinson's disease treatment by tracking them and reinforce the viability of cost effective, regular and precise telemonitoring application.

摘要

这项工作提出了更精确的计算方法,通过检测发音障碍来提高帕金森病的诊断。提出了新的方法来增强评估,并在早期识别受帕金森病影响的患者。分析具有显著的错误容忍率水平,并使用校正的 T 检验来建立我们的结果。这里使用了新的集成和其他机器学习方法,包括作为投影滤波器的 Haar 小波变换的多项式逻辑回归分类器,其性能优于逻辑回归。最后,提出了一种新颖可靠的推理系统,用于早期识别受这种疾病影响的人群,并提出了一种疾病严重程度的新度量标准。特征选择方法基于支持向量机和排名搜索方法。比较了每个模型的性能与现有方法,并检查了主要的改进,并得出了有利的结果。提出了可靠的方法来治疗帕金森病,包括稀疏多项式逻辑回归、贝叶斯网络、支持向量机、人工神经网络、提升方法及其集成。该研究旨在通过跟踪这些方法来提高帕金森病治疗的质量,并增强经济高效、定期和精确的远程监测应用的可行性。

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