Institute for Clinical Diabetology at German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany.
Diabetes Metab Res Rev. 2013 Feb;29(2):166-70. doi: 10.1002/dmrr.2378.
We investigated the adipokines adiponectin, leptin and resistin as serum biomarkers of beta-cell function in patients with type 1 diabetes.
One hundred and eighteen patients with type 1 diabetes (20.3 ± 7.5 years) diagnosed <5 years underwent standardized mixed meal test (MMTT) for 2 h. Systemic concentrations of C-peptide, adiponectin, leptin and resistin obtained during MMTT were measured and compared between patient groups by multiple regression analysis.
Patients were divided by their adipokine levels in subgroups above or below the median level ('high versus low'). High adiponectin levels (>10.6 µg/mL) were associated with lower C-peptide compared to the low adiponectin subgroup (p < 0.03). Increased leptin or resistin concentrations associated positively with beta-cell function even after adjustment for metabolic confounders (p < 0.04). The described associations between adipokines and C-peptide concentrations persisted in Spearman correlation tests (p < 0.05). Serum adipokines fell during MMTT (p < 0.05).
Serum adipokine levels differentially correlate with beta-cell function in type 1 diabetes independent of BMI or metabolic control. Serum adipokines should be investigated as biomarkers of beta-cell function in prospective studies and intervention trials in type 1 diabetes.
我们研究了脂肪细胞因子脂联素、瘦素和抵抗素，作为 1 型糖尿病患者胰岛β细胞功能的血清生物标志物。
118 例诊断时间<5 年的 1 型糖尿病患者（20.3±7.5 岁）进行 2 小时标准化混合餐试验（MMTT）。在 MMTT 期间测量获得的血清 C 肽、脂联素、瘦素和抵抗素浓度，并通过多元回归分析在患者组之间进行比较。
根据脂肪细胞因子水平将患者分为高于或低于中位数水平的亚组（“高与低”）。与低脂联素亚组相比，高脂联素水平（>10.6µg/ml）与 C 肽较低相关（p<0.03）。即使在调整代谢混杂因素后，增加的瘦素或抵抗素浓度也与胰岛β细胞功能呈正相关（p<0.04）。在 Spearman 相关检验中，脂联素与 C 肽浓度之间的相关性仍然存在（p<0.05）。在 MMTT 期间，血清脂肪细胞因子下降（p<0.05）。
血清脂肪细胞因子水平与 1 型糖尿病患者的胰岛β细胞功能相关，与 BMI 或代谢控制无关。在 1 型糖尿病的前瞻性研究和干预试验中，应进一步研究血清脂肪细胞因子作为胰岛β细胞功能的生物标志物。
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