运动诱导大鼠海马表观遗传参数的年龄依赖性变化：一项初步研究。
Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study.
机构信息
Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Rua Sarmento Leite, 500, 90050-170, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
Exp Gerontol. 2013 Feb;48(2):136-9. doi: 10.1016/j.exger.2012.11.011. Epub 2012 Nov 30.
Regular exercise improves learning and memory, including during aging process. Interestingly, the imbalance of epigenetic mechanisms has been linked to age-related cognitive deficits. However, studies about epigenetic alterations after exercise during the aging process are rare. In this preliminary study we investigated the effect of aging and exercise on DNA methyltransferases (DNMT1 and DNMT3b) and H3-K9 methylation levels in hippocampus from 3 and 20-months aged Wistar rats. The animals were submitted to two exercise protocols: single session or chronic treadmill protocol. DNMT1 and H3-K9 methylation levels were decreased in hippocampus from aged rats. The single exercise session decreased both DNMT3b and DNMT1 levels in young adult rats, without any effect in the aged group. Both exercise protocols reduced H3-K9 methylation levels in young adult rats, while the single session reversed the changes on H3-K9 methylation levels induced by aging. Together, these results suggest that an imbalance on DNMTs and H3-K9 methylation levels might be linked to the brain aging process and that the outcome to exercise seems to vary through lifespan.
定期运动可改善学习和记忆能力，包括在衰老过程中。有趣的是，表观遗传机制的失衡与年龄相关的认知缺陷有关。然而，关于衰老过程中运动后表观遗传改变的研究很少。在这项初步研究中，我们研究了衰老和运动对 3 个月和 20 个月大 Wistar 大鼠海马体中 DNA 甲基转移酶（DNMT1 和 DNMT3b）和 H3-K9 甲基化水平的影响。动物接受了两种运动方案：单次运动或慢性跑步机运动。海马体中 DNMT1 和 H3-K9 甲基化水平在老年大鼠中降低。单次运动降低了年轻成年大鼠的两种 DNMT3b 和 DNMT1 水平，但对老年组没有影响。两种运动方案都降低了年轻成年大鼠的 H3-K9 甲基化水平，而单次运动则逆转了由衰老引起的 H3-K9 甲基化水平的变化。综上所述，这些结果表明，DNMTs 和 H3-K9 甲基化水平的失衡可能与大脑衰老过程有关，而运动的结果似乎随着寿命的变化而变化。
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