一种与血小板衍生生长因子同源的血管内皮细胞促分裂原的氨基酸和cDNA序列。
Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.
作者信息
Conn G, Bayne M L, Soderman D D, Kwok P W, Sullivan K A, Palisi T M, Hope D A, Thomas K A
机构信息
Department of Biochemistry, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.
出版信息
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2628-32. doi: 10.1073/pnas.87.7.2628.
Abstract
Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.
摘要
胶质瘤衍生的血管内皮细胞生长因子（GD-VEGF）是一种46 kDa的二聚体糖蛋白促细胞分裂剂，与特征明确的成纤维细胞生长因子相比，它对血管内皮细胞的特异性明显更高。GD-VEGF cDNA序列编码一个由190个氨基酸残基组成的亚基，通过去除氨基末端的疏水分泌前导序列，该亚基转变为通过直接氨基酸测序表征的成熟的164个残基的亚基。GD-VEGF同型二聚体亚基与血小板衍生生长因子A链和B链及其癌基因同源物v-sis同源。
相似文献
1
Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2628-32. doi: 10.1073/pnas.87.7.2628.
2
Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family.
Biochem Biophys Res Commun. 1989 Dec 29;165(3):1198-206. doi: 10.1016/0006-291x(89)92729-0.
3
Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.
J Cell Biol. 1991 Sep;114(6):1285-94. doi: 10.1083/jcb.114.6.1285.
4
Vascular permeability factor, an endothelial cell mitogen related to PDGF.
Science. 1989 Dec 8;246(4935):1309-12. doi: 10.1126/science.2479987.
5
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9267-71. doi: 10.1073/pnas.88.20.9267.
6
Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line.
Proc Natl Acad Sci U S A. 1990 Feb;87(4):1323-7. doi: 10.1073/pnas.87.4.1323.
7
cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains.
Nature. 1987;328(6131):619-21. doi: 10.1038/328619a0.
8
A novel endothelial tyrosine kinase cDNA homologous to platelet-derived growth factor receptor cDNA.
Biochem Biophys Res Commun. 1992 Jul 31;186(2):706-14. doi: 10.1016/0006-291x(92)90804-t.
9
Molecular cloning of a novel bone-forming compound: osteoinductive factor.
DNA Cell Biol. 1990 Jun;9(5):303-9. doi: 10.1089/dna.1990.9.303.
10
The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.
EMBO J. 1984 May;3(5):921-8. doi: 10.1002/j.1460-2075.1984.tb01908.x.
引用本文的文献
1
Different evasion strategies in multiple myeloma.
Front Immunol. 2024 Feb 23;15:1346211. doi: 10.3389/fimmu.2024.1346211. eCollection 2024.
2
Assessment of angiogenic potential of mesenchymal stem cells derived conditioned medium from various oral sources.
J Clin Transl Res. 2022 Jul 25;8(4):323-338. eCollection 2022 Aug 29.
3
Ligands of the Neuropeptide Y Y2 Receptors as a Potential Multitarget Therapeutic Approach for the Protection of the Neurovascular Unit Against Acute Ischemia/Reperfusion: View from the Perspective of the Laboratory Bench.
Transl Stroke Res. 2022 Feb;13(1):12-24. doi: 10.1007/s12975-021-00930-4. Epub 2021 Jul 22.
4
Overview on the Different Patterns of Tumor Vascularization.
Cells. 2021 Mar 13;10(3):639. doi: 10.3390/cells10030639.
5
Transcriptomic profile of VEGF-regulated genes in human cervical epithelia.
Cell Tissue Res. 2021 Jun;384(3):771-788. doi: 10.1007/s00441-020-03354-y. Epub 2021 Jan 29.
6
Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers.
HIV AIDS (Auckl). 2017 Mar 30;9:77-93. doi: 10.2147/HIV.S124911. eCollection 2017.
7
Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression.
Oncotarget. 2017 Mar 21;8(12):20394-20409. doi: 10.18632/oncotarget.14610.
8
Vascular endothelial growth factor control mechanisms in skeletal growth and repair.
Dev Dyn. 2017 Apr;246(4):227-234. doi: 10.1002/dvdy.24463. Epub 2016 Dec 29.
9
Localization of vascular endothelial growth factor in nontumorous human pituitaries.
Endocr Pathol. 1999 Jun;10(2):109-22. doi: 10.1007/BF02739823.
10
The roles of vascular endothelial growth factor in bone repair and regeneration.
Bone. 2016 Oct;91:30-8. doi: 10.1016/j.bone.2016.06.013. Epub 2016 Jun 25.
本文引用的文献
1
A general method applicable to the search for similarities in the amino acid sequence of two proteins.
J Mol Biol. 1970 Mar;48(3):443-53. doi: 10.1016/0022-2836(70)90057-4.
2
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.
Cell. 1986 Jan 31;44(2):283-92. doi: 10.1016/0092-8674(86)90762-2.
3
A new method for predicting signal sequence cleavage sites.
Nucleic Acids Res. 1986 Jun 11;14(11):4683-90. doi: 10.1093/nar/14.11.4683.
4
Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain.
Nature. 1987;328(6131):621-4. doi: 10.1038/328621a0.
5
cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains.
Nature. 1987;328(6131):619-21. doi: 10.1038/328619a0.
6
Platelet-derived growth factor.
Annu Rev Med. 1987;38:71-9. doi: 10.1146/annurev.me.38.020187.000443.
7
Deletions in the N-terminal coding region of the v-sis gene: determination of the minimal transforming region.
J Virol. 1986 Aug;59(2):292-300. doi: 10.1128/JVI.59.2.292-300.1986.
8
Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2392-6. doi: 10.1073/pnas.83.8.2392.
9
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
Proc Natl Acad Sci U S A. 1988 Mar;85(5):1492-6. doi: 10.1073/pnas.85.5.1492.
10
Polypeptide growth factors: roles in normal and abnormal cell growth.
Annu Rev Cell Biol. 1987;3:443-92. doi: 10.1146/annurev.cb.03.110187.002303.
Zotero 插件