大鼠脾脏不同片段自体移植的组织学特征
Histological aspects of autologous transplantation of different fragments of the spleen in rats.
作者信息
Braga Ana Abreu, Malagó Rodolfo, Anacleto Thiago Pires, Silva Cristiano Rodrigo Nicomedes da, Andreollo Nelson Adami, Fernandes Fabio Luis Figueiredo
机构信息
School of Veterinary Medicine, University Center of Itajuba, MG, Brazil.
出版信息
Acta Cir Bras. 2012 Dec;27(12):880-4. doi: 10.1590/s0102-86502012001200009.
PURPOSE
To evaluate macro and microscopically the evolution of autotransplants of fragments of spleen different fragments in the greater omentum, after eight weeks of observation.
METHODS
Twenty rats Wistar were used, males and adults, submitted to total splenectomy and divided in two groups. The group I - ten animals with implant of spleen fragment (25% weight of spleen) in the omentum; and group II - ten animals with implant of spleen fragment (30% weight of spleen) in the omentum. It was analyzed macro and microscopically the evolution of the implant.
RESULTS
It was observed adherences to the adjacent tissues and vascularization in all of the fragments transplanted. The group I and II presented white pulp with follicular formations and lymphoid tissue preserved, and the red pulp in cordon aspect. The group II presented white pulp more disorganized and red pulp hemorrhagic. The active macrophages were observed in the group I and II.
CONCLUSION
The splenic autotransplantation of the group I showed better regeneration.
目的
在观察八周后，从宏观和微观层面评估大网膜中不同脾脏碎片自体移植的演变情况。
方法
使用20只成年雄性Wistar大鼠，进行全脾切除并分为两组。第一组——10只动物，将脾脏碎片（脾脏重量的25%）植入大网膜；第二组——10只动物，将脾脏碎片（脾脏重量的30%）植入大网膜。对植入物的演变进行宏观和微观分析。
结果
在所有移植的碎片中均观察到与相邻组织的粘连和血管形成。第一组和第二组均呈现出具有滤泡形成的白髓和保存的淋巴组织，红髓呈索状。第二组的白髓更紊乱，红髓有出血。在第一组和第二组中均观察到活跃的巨噬细胞。
结论
第一组的脾脏自体移植显示出更好的再生能力。
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