线粒体衍生肽人促素在应激抵抗中的新兴作用。
The emerging role of the mitochondrial-derived peptide humanin in stress resistance.
机构信息
USC Davis School of Gerontology, University of Southern California, Los Angeles, California 90089-0191, USA.
出版信息
J Mol Endocrinol. 2013 Jan 11;50(1):R11-9. doi: 10.1530/JME-12-0203. Print 2013 Feb.
Abstract
The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also improves cardiovascular disease as well as Alzheimer's disease in vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.
摘要
人类素的发现创造了一种新型的、源自线粒体的肽类，这可能是生物活性肽的一个新类别。随着更多的研究揭示人类素的内源性作用及其潜在的药理学用途，它在应激抵抗中的作用变得更加清晰。人类素可保护细胞免受体外氧化应激、血清饥饿、缺氧和其他损伤，还可改善体内的心血管疾病和阿尔茨海默病。在这篇综述中，我们讨论了人类素在应激抵抗中的新作用及其提出的作用机制。
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