阿魏酸对四氯化碳诱导的实验性大鼠高脂血症及组织学改变的保护作用。

Protective role of ferulic acid on carbon tetrachloride-induced hyperlipidemia and histological alterations in experimental rats.

作者信息

Marimuthu Srinivasan, Adluri Ram Sudheer, Rajagopalan Rukkumani, Menon Venugopal Padmanabhan

机构信息

Ayurveda Research Institute for Mother and Child Health Care, Poojappura, India.

出版信息

J Basic Clin Physiol Pharmacol. 2013;24(1):59-66. doi: 10.1515/jbcpp-2012-0053.

DOI:10.1515/jbcpp-2012-0053

PMID:23241587

Abstract

BACKGROUND

The present study aimed to evaluate the antihyperlipidemic effect of ferulic acid (FA) on carbon tetrachloride (CCl4)-treated rats.

METHODS

Female albino rats of the Wistar strain were used in the present study. The rats were divided into four groups: groups 1 and 4 received physiological saline (3 mL/kg body weight/week) by subcutaneous injection, whereas groups 2 and 3 received a subcutaneous injection of CCl4 (3 mL/kg body weight/week) for a total period of 12 weeks. In addition, groups 3 and 4 were administered FA (20 mL/kg body weight) every day for the last 90 days.

RESULTS

The results showed significantly (p≤0.05) elevated levels of cholesterol, triglycerides (TG), and free fatty acids (FFA) in the liver and kidney of CCl4-treated rats as compared with those of the controls. In addition, the levels of cholesterol, FFA, phospholipids (PL), and TG were elevated significantly in the circulation. Administration of FA effectively reduced these levels of lipids in the plasma, liver, and kidney of CCl4-treated rats. The PL level was significantly decreased in the liver and kidney of CCl4-treated rats and was positively modulated by FA treatment. Our histopathological observations were also in correlation with the biochemical parameters.

CONCLUSIONS

From the results obtained, we could conclude that FA effectively protects the system against hyperlipidemia and may be an effective therapeutic agent for the treatment of this disorder.

摘要

背景

本研究旨在评估阿魏酸（FA）对四氯化碳（CCl4）处理的大鼠的抗高血脂作用。

方法

本研究使用了Wistar品系的雌性白化大鼠。大鼠被分为四组：第1组和第4组皮下注射生理盐水（3 mL/kg体重/周），而第2组和第3组皮下注射CCl4（3 mL/kg体重/周），共持续12周。此外，在最后90天，第3组和第4组每天给予FA（20 mL/kg体重）。

结果

结果显示，与对照组相比，CCl4处理的大鼠肝脏和肾脏中的胆固醇、甘油三酯（TG）和游离脂肪酸（FFA）水平显著升高（p≤0.05）。此外，循环中的胆固醇、FFA、磷脂（PL）和TG水平也显著升高。给予FA有效降低了CCl4处理的大鼠血浆、肝脏和肾脏中的这些脂质水平。CCl4处理的大鼠肝脏和肾脏中的PL水平显著降低，而FA处理对其有正向调节作用。我们的组织病理学观察结果也与生化参数相关。