通过立体光刻技术构建用于生物医学用途的具有形状记忆性能的聚合物微结构。
Polymeric microstructures with shape-memory properties for biomedical use built by stereolithography.
机构信息
Department of Biomedical Engineering, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands.
出版信息
J Appl Biomater Funct Mater. 2012;10(3):280-6. doi: 10.5301/JABFM.2012.10367.
PURPOSE
The aim of this study was to design and build porous microstructures with shape memory behaviour using biodegradable poly(D,L-lactide-co-trimethylene carbonate) dimethacrylate macromers. These microstructures could be advantageous for tissue engineering and other advanced biomedical applications.
METHODS
Porous structures with a gyroid pore network architecture showing average pore sizes of 930 µm and complete pore interconnectivity were prepared by stereolithography. Built structures were characterized by Micro-computed tomography (µ-CT). Shape recovery and shape fixity of microstructures after 40% and 70% compression were evaluated.
RESULTS
At 37 °C the flexible structures showed compression modulus values of 60 KPa and could be fully compressed. Thermal analysis showed that the built networks were amorphous with Tg values of 23 °C. After compression to 40 and 70%, shape fixity and shape recovery of the structures at respectively 0 °C and 37 °C was almost quantitative.
CONCLUSIONS
The well-defined pore network characteristics and the shape-memory properties of these structures allow their use as deployable tissue engineering scaffolds.
目的
本研究旨在设计和制造具有形状记忆行为的多孔微观结构，使用可生物降解的聚（D，L-丙交酯-共-三亚甲基碳酸酯）二甲基丙烯酸酯大分子单体。这些微观结构可能有利于组织工程和其他先进的生物医学应用。
方法
通过立体光刻技术制备具有具有面心立方孔网络结构的多孔结构，显示平均孔径为 930 µm 且完全连通。通过微计算机断层扫描（µ-CT）对构建结构进行了表征。评估了微观结构在 40%和 70%压缩后的形状恢复和形状固定性。
结果
在 37°C 时，柔性结构的压缩模量值为 60 KPa，可以完全压缩。热分析表明，所构建的网络为无定形，玻璃化转变温度（Tg）值为 23°C。在分别压缩至 40%和 70%后，结构在 0°C 和 37°C 下的形状固定性和形状恢复率几乎达到定量。
结论
这些结构具有良好定义的孔网络特征和形状记忆性能，可作为可展开的组织工程支架使用。
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