钯催化的 O-甲基酮肟与α-酮酸的脱羧酰化反应。

Palladium-catalyzed decarboxylative acylation of O-methyl ketoximes with α-keto acids.

机构信息

School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.

出版信息

Chem Commun (Camb). 2013 Jan 30;49(9):925-7. doi: 10.1039/c2cc38433g.

Abstract

A mild, practical and efficient palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-keto acids via C-H bond activation is described. In these reactions, a broad range of O-methyl ketoximes and α-keto acids undergoes the decarboxylative cross-coupling reactions with high selectivities and good tolerance.

摘要

描述了一种温和、实用且高效的钯催化的通过 C-H 键活化的 O-甲基酮肟与α-酮酸的邻位酰化反应。在这些反应中，广泛的 O-甲基酮肟和α-酮酸经历脱羧交叉偶联反应，具有高选择性和良好的耐受性。