Ding Yong Hong, Tieu Tai, Kallmes David F
Department of Radiology, Neuroradiology Research Laboratory, Mayo Clinic, Rochester, Minnesota, USA.
J Neurointerv Surg. 2014 Jan;6(1):29-31. doi: 10.1136/neurintsurg-2012-010575. Epub 2012 Dec 20.
To explore the patency and growth of surgical sidewall aneurysms in rabbits.
Forty sidewall aneurysms were created in the right common carotid artery (RCCA). Intravenous digital subtraction angiography (DSA) through the ear vein was performed immediately after creation. Three weeks later, intra-arterial DSA through the femoral artery was performed. Aneurysm sizes (neck, width, height and volume) were measured and calculated immediately after creation and 3 weeks later. Aneurysm patency after creation was evaluated. Differences in aneurysm sizes immediately after creation and 3 weeks later were compared using the Student's t test.
Aneurysms and the parent artery remained patent in 38 (95%) of the 40 rabbits 3 weeks after creation. Two other rabbits (5%) showed aneurysm occlusion. There was a significant difference in aneurysm neck size 3 weeks after creation (3.6±0.9 mm vs 2.4±0.4 mm, p<0.0001). The aneurysm became wider 3 weeks later (5.8±1.5 mm vs 4.3±1.2 mm, p<0.0001). Aneurysm length was also larger than immediately after creation (6.1±1.3 mm vs 4.3±1.4 mm, p<0.0001). The aneurysm volume was larger than that created immediately (127.5±89.4 mm(3) vs 51.0±34.9 mm(3), p<0.0001).
The patency rate of sidewall aneurysms in rabbits is high. The aneurysm keeps growing for at least 3 weeks after creation.
探讨兔手术侧壁动脉瘤的通畅情况及生长情况。
在兔右侧颈总动脉（RCCA）制作40个侧壁动脉瘤。制作完成后立即经耳静脉行静脉数字减影血管造影（DSA）。3周后，经股动脉行动脉内DSA。在制作完成后及3周后立即测量并计算动脉瘤大小（颈部、宽度、高度和体积）。评估制作后动脉瘤的通畅情况。采用Student's t检验比较制作完成后及3周后动脉瘤大小的差异。
40只兔中有38只（95%）在制作后3周动脉瘤及其供血动脉保持通畅。另外2只兔（5%）出现动脉瘤闭塞。制作后3周动脉瘤颈部大小有显著差异（3.6±0.9mm对2.4±0.4mm，p<0.0001）。3周后动脉瘤变宽（5.8±1.5mm对4.3±1.2mm，p<0.0001）。动脉瘤长度也比制作完成后增大（6.1±1.3mm对4.3±1.4mm，p<0.0001）。动脉瘤体积比制作完成时增大（127.5±89.4mm³对51.0±34.9mm³，p<0.0001）。
兔侧壁动脉瘤的通畅率较高。动脉瘤在制作后至少3周持续生长。
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