非 ST 段抬高型心肌梗死患者冠状动脉侧支循环与红细胞分布宽度的关系。
Relation of coronary collateral circulation with red cell distribution width in patients with non-ST elevation myocardial infarction.
机构信息
1Department of Cardiology, Heart Center, Ataturk University Medical School, Erzurum, Turkey.
出版信息
Clin Appl Thromb Hemost. 2014 May;20(4):411-5. doi: 10.1177/1076029612470490. Epub 2012 Dec 21.
OBJECTIVES
We aimed to investigate the relationship between red cell distribution width (RDW) value and coronary collateral circulation (CCC) in patients with non-ST elevation myocardial infarction (NSTEMI).
METHODS
The study population consisted of 322 consecutive patients with NSTEMI. The patients were classified into impaired CCC (group 1, Rentrop grades 0-1) or good CCC (group 2, Rentrop grades 2-3). Baseline RDW was measured as part of the automated complete blood count.
RESULTS
The RDW values were significantly higher in patients with impaired CCC than in those with good CCC (17.2 ± 2.3 vs 14.5 ± 2.5, P < .001). In multivariate logistic regression analysis, RDW (odds ratio: 1.52, 95% confidence interval: 1.30-1.78, P < .001), baseline creatine kinase MB (CK-MB), and absence of preinfarction angina were found to be the independent predictors of impaired CCC. In receiver-operating characteristic curve analysis, the RDW value >15.5 yielded an area under curve value of 0.783, with 77% sensitivity and 73% specificity.
CONCLUSIONS
Our study results demonstrated that, high RDW, high CK-MB, and absence of preinfarction angina were found to be independent predictors of impaired CCC.
目的
本研究旨在探讨非 ST 段抬高型心肌梗死（NSTEMI）患者红细胞分布宽度（RDW）值与侧支循环（CCC）之间的关系。
方法
本研究纳入了 322 例连续 NSTEMI 患者。根据Rentrop 分级（0-1 级为侧支循环不良组，2-3 级为侧支循环良好组）将患者分为两组。基线 RDW 通过自动全血细胞计数进行测量。
结果
侧支循环不良组患者的 RDW 值明显高于侧支循环良好组（17.2±2.3 比 14.5±2.5，P<0.001）。多因素 logistic 回归分析显示，RDW（比值比：1.52，95%置信区间：1.30-1.78，P<0.001）、基线肌酸激酶同工酶 MB（CK-MB）和无梗死前心绞痛是侧支循环不良的独立预测因素。受试者工作特征曲线分析显示，RDW 值>15.5 的曲线下面积为 0.783，具有 77%的敏感性和 73%的特异性。
结论
本研究结果表明，高 RDW、高 CK-MB 和无梗死前心绞痛是侧支循环不良的独立预测因素。
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