晚钠电流——起源及病理生理学意义 - Suppr

The late Na+ current--origin and pathophysiological relevance.

作者信息

Zaza Antonio, Rocchetti Marcella

机构信息

Dipartimento di Biotecnologie e Bioscienze, Università degli Studi Milano-Bicocca, Milano, Italy,

出版信息

Cardiovasc Drugs Ther. 2013 Feb;27(1):61-8. doi: 10.1007/s10557-012-6430-0.

DOI:10.1007/s10557-012-6430-0

PMID:23274937

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3555240/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d388/3555240/4b2060b0d877/10557_2012_6430_Fig1_HTML.jpg

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The late Na+ current--origin and pathophysiological relevance.

Cardiovasc Drugs Ther. 2013 Feb;27(1):61-8. doi: 10.1007/s10557-012-6430-0.

Selective inhibition of physiological late Na current stabilizes ventricular repolarization.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H236-H245. doi: 10.1152/ajpheart.00071.2017. Epub 2017 Sep 29.

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J Cardiovasc Electrophysiol. 2010 Aug 1;21(8):916-22. doi: 10.1111/j.1540-8167.2009.01713.x. Epub 2010 Feb 1.

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Heart Rhythm. 2016 Nov;13(11):2228-2236. doi: 10.1016/j.hrthm.2016.08.007. Epub 2016 Aug 3.

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Front Pharmacol. 2020 Apr 20;11:413. doi: 10.3389/fphar.2020.00413. eCollection 2020.

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Circ Arrhythm Electrophysiol. 2020 Apr;13(4):e008130. doi: 10.1161/CIRCEP.119.008130. Epub 2020 Mar 23.

Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.

Circ Res. 2012 Jul 20;111(3):322-32. doi: 10.1161/CIRCRESAHA.112.265173. Epub 2012 Jun 20.

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J Neurosci. 2012 Feb 22;32(8):2714-21. doi: 10.1523/JNEUROSCI.5088-11.2012.

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J Mol Med (Berl). 2012 Jan;90(1):31-43. doi: 10.1007/s00109-011-0804-9. Epub 2011 Aug 28.

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Cardiovasc Hematol Agents Med Chem. 2011 Jul 1;9(3):190-206. doi: 10.2174/187152511797037583.

A Brugada syndrome mutation (p.S216L) and its modulation by p.H558R polymorphism: standard and dynamic characterization.

Cardiovasc Res. 2011 Sep 1;91(4):606-16. doi: 10.1093/cvr/cvr142. Epub 2011 Jun 24.

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.

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