Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, United Kingdom.
J Clin Invest. 2013 Jan;123(1):92-100. doi: 10.1172/JCI62874. Epub 2013 Jan 2.
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.
急性心肌梗死(MI)是全球范围内导致死亡和残疾的主要原因。在 MI 患者中,使用溶栓治疗或直接经皮冠状动脉介入治疗(PPCI)进行及时有效的心肌再灌注是减少急性心肌缺血损伤和限制 MI 面积的首选治疗方法。然而,再灌注过程本身可诱导心肌细胞死亡,称为心肌再灌注损伤,目前对此尚无有效的治疗方法。目前正在研究的许多用于预防心肌再灌注损伤的新治疗策略,有可能改善接受 PPCI 治疗的急性 MI 患者的临床结局。