聚焦磁共振引导聚焦超声治疗前列腺癌：北美初步经验。
Focal magnetic resonance guided focused ultrasound for prostate cancer: Initial North American experience.
作者信息
Lindner Uri, Ghai Sangeet, Spensieri Paula, Hlasny Eugen, Van Der Kwast Theodorus H, McCluskey Stuart A, Haider Masoom A, Kucharczyk Walter, Trachtenberg John
机构信息
Division of Urology, Department of Surgical Oncology, University Health Network, and Department of Surgery, University of Toronto, Toronto, ON;
出版信息
Can Urol Assoc J. 2012 Dec;6(6):E283-6. doi: 10.5489/cuaj.12218.
The treatment of low-risk prostate cancer is a common clinical dilemma between standard curative whole gland therapy (and its associated quality of life diminishing side effects) and active surveillance (and its low, but real, risk of progression). The goal of focal therapy in low-risk prostate cancer is to achieve the best balance between cancer control and maintenance of quality of life. Magnetic resonance-guided focused ultrasound (MRgFUS) surgery is a non-invasive thermal ablation method that integrates magnetic resonance imaging for target identification, treatment planning and closed-loop control of thermal deposition and focused ultrasound for thermal ablation of the tumour target. This novel transrectal system allows for tumour localization, targeting and monitoring of tumour target ablation in real time, while simultaneously preserving adjacent normal tissue thereby minimizing the side effects of standard curative surgical or radiation therapy. We report the first North American clinical experience of treatment of localized prostate cancer with focal MR-guided transrectal focused ultrasound (clinicaltrial.gov identifier NCT01226576).
低风险前列腺癌的治疗是一个常见的临床难题，存在于标准的根治性全腺治疗（及其相关的影响生活质量的副作用）和主动监测（及其低但真实存在的进展风险）之间。低风险前列腺癌聚焦治疗的目标是在癌症控制和生活质量维持之间实现最佳平衡。磁共振引导聚焦超声（MRgFUS）手术是一种非侵入性热消融方法，它整合了用于目标识别、治疗规划以及热沉积闭环控制的磁共振成像和用于肿瘤目标热消融的聚焦超声。这种新型经直肠系统能够实时进行肿瘤定位、靶向以及对肿瘤目标消融进行监测，同时保留相邻正常组织，从而将标准根治性手术或放射治疗的副作用降至最低。我们报告了北美首例使用聚焦磁共振引导经直肠聚焦超声治疗局限性前列腺癌的临床经验（临床试验.gov标识符NCT01226576）。
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