中年和老年中国女性的流产史与非酒精性脂肪肝之间的关联。
Association between history of abortion and nonalcoholic fatty liver disease in middle-aged and elderly Chinese women.
机构信息
Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
出版信息
Ann Epidemiol. 2013 Mar;23(3):119-23. doi: 10.1016/j.annepidem.2012.12.002. Epub 2013 Jan 5.
PURPOSE
To evaluate the possible relationship between self-reported history of abortion and nonalcoholic fatty liver disease (NAFLD) in middle-aged and elderly Chinese women.
METHODS
A cross-sectional study was performed in 5911 women aged 40 years or older in Jiading District, Shanghai, China. Reproductive histories, including miscarriage and induced abortion, were collected using a validated questionnaire by trained physicians. Abdominal B-mode ultrasound evaluation and serum liver enzymes levels were used in the diagnosis of NAFLD.
RESULTS
The percentage reporting history of abortion in women with NAFLD was higher than in those without NAFLD (72.4% vs. 69.3%, age-adjusted P = .001). Compared with women without a history of abortion, the fully adjusted odds ratio (OR) for NAFLD in those with a history of abortion was increased by 28% (OR, 1.28 and 95% confidence interval [CI], 1.06-1.55). Histories of miscarriage and induced abortion were also associated with increased risk of prevalent NAFLD in fully adjusted models (OR, 1.84 and 95% CI, 1.24-2.72; OR, 1.23 and 95% CI, 1.02-1.50, respectively).
CONCLUSIONS
Both miscarriage and induced abortion are associated with prevalent NAFLD in middle-aged and elderly Chinese women.
目的
评估中年和老年中国女性自述流产史与非酒精性脂肪性肝病（NAFLD）之间的可能关系。
方法
在中国上海嘉定区对 5911 名年龄在 40 岁及以上的女性进行了一项横断面研究。由经过培训的医生使用经过验证的问卷收集生育史，包括自然流产和人工流产。腹部 B 型超声检查和血清肝酶水平用于诊断 NAFLD。
结果
报告有 NAFLD 史的女性中流产史的比例高于无 NAFLD 史的女性（72.4%比 69.3%，年龄调整后 P =.001）。与无流产史的女性相比，有流产史的女性患 NAFLD 的完全调整比值比（OR）增加了 28%（OR，1.28 和 95%置信区间[CI]，1.06-1.55）。在完全调整的模型中，自然流产和人工流产史也与患常见 NAFLD 的风险增加相关（OR，1.84 和 95%CI，1.24-2.72；OR，1.23 和 95%CI，1.02-1.50）。
结论
自然流产和人工流产均与中年和老年中国女性常见的 NAFLD 相关。
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