深穴穴醚合成受体用于人尿液中小分子的 1H NMR 检测。
1H NMR detection of small molecules in human urine with a deep cavitand synthetic receptor.
机构信息
The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
Analyst. 2013 Feb 21;138(4):1008-10. doi: 10.1039/c2an36635e.
PMID:23304698
Abstract
A water-soluble deep cavitand recognized alkylammonium salts, including the drug amantadine hydrochloride, in spiked samples of human urine. The signals of the guests are detected by (1)H NMR upfield of 0 ppm and so occur in a spectroscopic window that is outside of the normal region and distinct from the signals of the biofluid components.
摘要
水溶性深穴包合物可识别包括金刚烷胺盐酸盐在内的烷基铵盐，可在人尿的加标样品中检测到客体的信号。这些信号通过 (1)H NMR 在 0 ppm 向上场检测，因此出现在光谱窗口之外的正常区域，与生物流体成分的信号不同。
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