结核分枝杆菌中外排泵对肽聚糖合成抑制剂耐药性的作用。
Involvement of efflux pumps in the resistance to peptidoglycan synthesis inhibitors in Mycobacterium tuberculosis.
机构信息
AstraZeneca India, Hebbal, Bangalore, India.
出版信息
Antimicrob Agents Chemother. 2013 Apr;57(4):1941-3. doi: 10.1128/AAC.01957-12. Epub 2013 Jan 18.
Abstract
We evaluated the contributions of Mycobacterium tuberculosis efflux pumps towards intrinsic resistance to different classes of peptidoglycan synthesis inhibitors (PSI). Our study indicates that the efflux pump knockout strains are more susceptible to PSI than the wild type. Vancomycin and ceftriaxone exhibited up to 3 log increased kill on efflux pump mutants compared to the wild-type strain, strongly suggesting an important role for efflux pumps in the intrinsic resistance of M. tuberculosis to PSI.
摘要
我们评估了分枝杆菌外排泵对不同类型肽聚糖合成抑制剂（PSI）固有耐药性的贡献。我们的研究表明，与野生型相比，外排泵敲除菌株对 PSI 更敏感。与野生型菌株相比，万古霉素和头孢曲松对外排泵突变体的杀菌效果增加了高达 3 个对数级，这强烈表明外排泵在结核分枝杆菌对 PSI 的固有耐药性中起着重要作用。
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