Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China.
Int J Mol Sci. 2013 Jan 25;14(2):2431-48. doi: 10.3390/ijms14022431.
Senescent cells are relatively stable, lacking proliferation capacity yet retaining metabolic activity. In contrast, cancer cells are rather invasive and devastating, with uncontrolled proliferative capacity and resistance to cell death signals. Although tumorigenesis and cellular senescence are seemingly opposite pathological events, they are actually driven by a unified mechanism: DNA damage. Integrity of the DNA damage response (DDR) network can impose a tumorigenesis barrier by navigating abnormal cells to cellular senescence. Compromise of DDR, possibly due to the inactivation of DDR components, may prevent cellular senescence but at the expense of tumor formation. Here we provide an overview of the fundamental role of DDR in tumorigenesis and cellular senescence, under the light of the Yin-Yang concept of Chinese philosophy. Emphasis is placed on discussing DDR outcome in the light of in vivo models. This information is critical as it can help make better decisions for clinical treatments of cancer patients.
衰老细胞相对稳定，缺乏增殖能力但保留代谢活性。相比之下，癌细胞具有侵袭性和破坏性，增殖能力不受控制且对细胞死亡信号有抗性。虽然肿瘤发生和细胞衰老似乎是相反的病理事件，但它们实际上是由一个统一的机制驱动的：DNA 损伤。DNA 损伤反应 (DDR) 网络的完整性可以通过将异常细胞引导到细胞衰老来形成肿瘤发生的障碍。DDR 的破坏，可能由于 DDR 成分的失活，可能阻止细胞衰老，但代价是肿瘤形成。在这里，我们根据中国哲学的阴阳概念，概述了 DDR 在肿瘤发生和细胞衰老中的基本作用。重点讨论了根据体内模型讨论 DDR 结果。这些信息至关重要，因为它可以帮助癌症患者的临床治疗做出更好的决策。
