严重创伤后骨关节炎的遗传贡献。
The genetic contribution to severe post-traumatic osteoarthritis.
机构信息
Academic Rheumatology, Nottingham City Hospital, Nottingham, UK.
出版信息
Ann Rheum Dis. 2013 Oct;72(10):1687-90. doi: 10.1136/annrheumdis-2012-202562. Epub 2013 Jan 26.
OBJECTIVE
to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement.
METHODS
A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates.
RESULTS
For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10⁻⁵). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10⁻⁵) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063).
CONCLUSIONS
Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.
目的
比较与膝或髋关节骨关节炎（OA）风险相关的遗传变异位点在导致全关节置换的临床严重 OA 的创伤后（PT）和非创伤后（NT）病例中的联合作用。
方法
共有来自 2 个英国队列的 1590 名对照、2168 例全膝关节置换术（TKR）病例（33.2%PT）和 1567 例全髋关节置换术（THR）病例（8.7%PT）进行了 12 种先前报道与膝或髋 OA 风险具有可重复性相关的变体的基因分型。生成了遗传风险评分，并在调整协变量后评估了其与 PT 和 NT TKR 和 THR 的关联。
结果
对于 THR，每个额外的遗传风险变异在 PT 病例中赋予的风险较低（OR=1.07，95%CI 0.96 至 1.19；p=0.24），而在 NT 病例中则较高（OR 1.11，95%CI 1.06 至 1.17；p=1.55×10⁻⁵）。相比之下，对于 TKR，每个风险变异在 PT 病例中赋予的风险略高于 NT 病例（OR 1.12，95%CI 1.07 至 1.19；p=1.82×10⁻⁵），而在 NT 病例中则较低（OR 1.08，95%CI 1.03 至 1.1；p=0.00063）。
结论
根据迄今为止报道的变体，PT TKR 病例的遗传贡献至少与 NT 病例一样高。
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