入住新生儿重症监护病房的婴儿的巨细胞病毒感染
Cytomegalovirus infection in infants admitted to a neonatal intensive care unit.
作者信息
Narvaez-Arzate Ricardo V, Olguin-Mexquitic Leticia, Lima-Rogel Victoria, Noyola Daniel E, Barrios-Compean Lidia M, Villegas-Alvarez Carolina
机构信息
Neonatology Service, Pediatrics Division, Hospital Central Dr Ignacio Morones Prieto, San Luis Potosí, México.
出版信息
J Matern Fetal Neonatal Med. 2013 Jul;26(11):1103-6. doi: 10.3109/14767058.2013.770459. Epub 2013 Feb 27.
OBJECTIVES
To determine the incidence of congenital cytomegalovirus (CMV) infection and the frequency of postnatal infection in a neonatal intensive care unit (NICU).
METHODS
Urine samples of 135 infants who were admitted to the NICU during a 6 month period were evaluated to detect CMV using a nested PCR assay. A breast milk sample was obtained to determine viral excretion. Clinical characteristics of infected and non-infected infants were compared.
RESULTS
Congenital CMV infection was confirmed in two (1.48%) infants. Post-natal infection was documented in four of 36 (11.1%) infants that were evaluated. CMV excretion was detected in 43 of 116 mothers. Gestational age of infants born to mothers who excreted CMV was shorter than that of infants of mothers with negative results (33.1 versus 34.2 weeks; p = 0.07).
CONCLUSIONS
CMV excretion in breast milk is frequent and is associated to congenital and postnatal infection. Further studies are necessary to assess the impact of CMV infection during pregnancy and neonatal outcomes.
目的
确定新生儿重症监护病房（NICU）中先天性巨细胞病毒（CMV）感染的发生率以及产后感染的频率。
方法
对在6个月期间入住NICU的135名婴儿的尿液样本进行评估，采用巢式PCR检测法检测CMV。采集母乳样本以确定病毒排泄情况。比较感染和未感染婴儿的临床特征。
结果
两名（1.48%）婴儿确诊为先天性CMV感染。在接受评估的36名婴儿中有4名（11.1%）记录有产后感染。在116名母亲中的43名检测到CMV排泄。排泄CMV的母亲所生婴儿的胎龄短于检测结果为阴性的母亲所生婴儿（33.1周对34.2周；p = 0.07）。
结论
母乳中CMV排泄很常见，且与先天性和产后感染有关。有必要进一步研究以评估孕期CMV感染的影响及新生儿结局。
Zotero 插件