中国广州地区过敏患者对屋尘螨和贮藏螨 IgE 的反应性。

House dust mite and storage mite IgE reactivity in allergic patients from Guangzhou, China.

机构信息

State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

出版信息

Asian Pac J Allergy Immunol. 2012 Dec;30(4):294-300.

PMID:23393909

Abstract

BACKGROUND

In China, house dust mites are important inducers of allergic disease. The importance of allergens from storage mites is less well known.

OBJECTIVE

The aim of this study is to access the prevalence of house dust mite and storage mite sensitization and investigate the IgE crossreactivity between house dust mite and storage mite.

METHOD

The skin prick test (SPT) and specific IgE against the mite species D. pteronyssinus, D. farinae, B. tropicalis, Lepidoglyphus destructor, Glycyphagus domesticus, Tyrophagus putrescentiae and Acarus siro were measured. Included were 412 patients with asthma and/or rhinitis for SPT, 244 for specific IgE and 29 sera for IgE inhibition studies.

RESULTS

The positive SPT prevalence for D. pteronyssinus was 80.3% and for D. farinae 83.7%. The specific IgE prevalence for D. pteronyssinus was 61.1% and for D. farinae 60.2%. The storage mite species, B. tropicalis and T. putrescentiae had the highest positive SPT prevalence, 66% and 63%, respectively. The specific IgE prevalence was highest for B. tropicalis and G. domesticus, 41% and 37%, respectively. Both SPT and specific IgE levels were much higher for house dust mites compared to storage mites. Inhibition measurements showed that none of the storage mites could fully inhibit the specific IgE against D. pteronyssinus. Only in half of the sera could D. pteronyssinus fully inhibit the IgE against L. destructor and G. domesticus while inhibition of the other storage mites were much lower. Nearly all the specific IgE against storage mites could be inhibited by the other storage mites, though B. tropicalis showed a slightly different pattern from the other storage mites.

CONCLUSION

IgE reactivity against storage mites in Chinese patients is due to both storage mite specific IgE and due to IgE mediated crossreactivity to D. pteronyssinus.

摘要

背景

在中国，屋尘螨是引发过敏疾病的重要过敏原。而储尘螨过敏原的重要性则鲜为人知。

目的

本研究旨在评估屋尘螨和储尘螨致敏的流行情况，并探讨屋尘螨和储尘螨之间 IgE 的交叉反应性。

方法

采用皮肤点刺试验（SPT）和针对屋尘螨种 D. pteronyssinus、D. farinae、B. tropicalis、Lepidoglyphus destructor、Glycyphagus domesticus、Tyrophagus putrescentiae 和 Acarus siro 的特异性 IgE 进行检测。包括 412 例哮喘和/或鼻炎患者进行 SPT 检测，244 例进行特异性 IgE 检测，29 例进行 IgE 抑制研究。

结果

屋尘螨 D. pteronyssinus 的阳性 SPT 流行率为 80.3%，D. farinae 为 83.7%。屋尘螨 D. pteronyssinus 的特异性 IgE 流行率为 61.1%，D. farinae 为 60.2%。储尘螨种 B. tropicalis 和 T. putrescentiae 的阳性 SPT 流行率最高，分别为 66%和 63%。特异性 IgE 流行率最高的是 B. tropicalis 和 G. domesticus，分别为 41%和 37%。与储尘螨相比，屋尘螨的 SPT 和特异性 IgE 水平均高得多。抑制测量表明，没有一种储尘螨可以完全抑制针对 D. pteronyssinus 的特异性 IgE。只有一半的血清中，D. pteronyssinus 可以完全抑制针对 L. destructor 和 G. domesticus 的 IgE，而对其他储尘螨的抑制作用则低得多。几乎所有针对储尘螨的特异性 IgE 都可以被其他储尘螨抑制，尽管 B. tropicalis 的抑制模式与其他储尘螨略有不同。