Division of Pediatric Allergy, Bezmialem Vakif University, Istanbul, Turkey.
Am J Rhinol Allergy. 2013 Jan;27(1):13-7. doi: 10.2500/ajra.2013.27.3837.
Oxidative stress may play a role in the pathophysiology of several diseases including allergic rhinitis (AR). In children with AR an antioxidant enzyme paraoxonase (PON1) has not been previously investigated. The aim of this study was to investigate plasma PON1 activity and plasma total oxidant status (TOS), which are in the form of plasma reactive oxidants, and their association with severity of disease in house-mite-sensitive children with AR.
This study included 66 children with persistent AR and 40 healthy controls aged between 7 and 12 years old. Plasma PON1, TOS, and total serum immunoglobulin E (IgE) were measured. The nasal symptom scores and body mass index were evaluated at the time of blood collection.
Mean serum PON1 levels were significantly lower and, TOS levels were higher in the patient group than in the control group (p ≤ 0.001 and p ≤ 0.002, respectively). A significant negative correlation was observed between serum levels of PON1 and nasal symptom scores. However, serum levels of TOS were correlated with nasal symptom scores positively. There were no correlations between levels of total IgE and levels of PON1 and TOS levels.
Plasma PON1 and TOS levels may serve as predictors of disease severity in children with AR and both of them appear to be attractive candidates for modulating inflammation in AR.
氧化应激可能在包括过敏性鼻炎（AR）在内的几种疾病的病理生理学中发挥作用。在患有 AR 的儿童中，抗氧化酶对氧磷酶（PON1）尚未得到研究。本研究的目的是研究血浆 PON1 活性和血浆总氧化剂状态（TOS），它们以血浆活性氧化剂的形式存在，及其与屋尘螨敏感的 AR 儿童疾病严重程度的关系。
本研究包括 66 名持续性 AR 儿童和 40 名年龄在 7 至 12 岁之间的健康对照者。测量了血浆 PON1、TOS 和总血清免疫球蛋白 E（IgE）。在采血时评估了鼻症状评分和体重指数。
患者组的平均血清 PON1 水平明显低于对照组，TOS 水平也高于对照组（p ≤ 0.001 和 p ≤ 0.002）。血清 PON1 水平与鼻症状评分呈显著负相关。然而，TOS 血清水平与鼻症状评分呈正相关。总 IgE 水平与 PON1 和 TOS 水平之间没有相关性。
血浆 PON1 和 TOS 水平可能是 AR 儿童疾病严重程度的预测因子，两者似乎都是调节 AR 中炎症的有吸引力的候选物。
