Department of Pediatrics, Reinier de Graaf Hospital, Delft, The Netherlands.
Alcohol Clin Exp Res. 2013 Jul;37(7):1188-94. doi: 10.1111/acer.12090. Epub 2013 Feb 26.
The prevalence of adolescents hospitalized with acute alcohol intoxication, mainly because of severe reduced consciousness, is increasing. However, the characteristics of these adolescents are mainly unidentified. In this clinical research, we aimed to identify factors that attribute to higher ethanol concentration, on which targeted alcohol health interventions can be designed.
Since 2007, alcohol intoxication among adolescents has been one of the leading topics of the Dutch Pediatric Surveillance System. In the current study, we have analyzed which demographic characteristics, general alcohol use behaviors, and clinical intoxication data were related to the blood alcohol concentration (BAC) levels at hospital admittance. We included all adolescents aged <18 years, admitted with BAC >0.0 g/l, and reduced consciousness during the years 2007, 2008, 2009, and 2010.
A total of 2,023 adolescents with alcohol intoxication were reported, and 1,618 questionnaires were returned, of which 1,350 met our inclusion criteria. In univariate analysis, age, gender, educational level, place of alcohol purchase, place of alcohol consumption, age of first drink, and regular alcohol use during the weekend correlated with higher BAC. After multivariate analysis, older adolescents, boys, and higher educational level significantly attributed to higher BAC at admittance.
In alcohol-intoxicated adolescents with reduced consciousness, gender, age, and also educational level correlate with BAC at admittance. Explanatory factors could be found in sensitivity to alcohol, but also in socioeconomic factors, which influence availability. Intervention strategies could be targeted more specific now for the subgroups found in this study to decrease the growing burden of adolescent alcohol intoxication, both on the societal level and on the clinical level.
因严重意识降低而住院的急性酒精中毒青少年的患病率正在上升。然而,这些青少年的特征主要未被识别。在这项临床研究中,我们旨在确定导致更高乙醇浓度的因素,以便针对这些因素设计有针对性的酒精健康干预措施。
自 2007 年以来,青少年酒精中毒一直是荷兰儿科监测系统的主要课题之一。在本研究中,我们分析了哪些人口统计学特征、一般饮酒行为和临床中毒数据与入院时的血液酒精浓度(BAC)水平相关。我们纳入了所有年龄<18 岁、BAC>0.0g/l 且意识降低的青少年,并分析了 2007、2008、2009 和 2010 年的数据。
共报告了 2023 例青少年酒精中毒患者,其中 1618 例返回了问卷,其中 1350 例符合我们的纳入标准。单因素分析显示,年龄、性别、教育程度、酒精购买地点、饮酒地点、首次饮酒年龄和周末饮酒频率与较高的 BAC 相关。多因素分析后,年龄较大的青少年、男孩和较高的教育程度显著导致入院时 BAC 升高。
在意识降低的酒精中毒青少年中,性别、年龄和教育程度与入院时的 BAC 相关。可以在敏感性、社会经济因素等方面找到解释因素,这些因素影响了酒精的可获得性。现在可以针对本研究中发现的亚组制定更有针对性的干预策略,以降低青少年酒精中毒的日益增长的负担,无论是在社会层面还是临床层面。