Eefting D, Ultee K H J, Von Meijenfeldt G C I, Hoeks S E, ten Raa S, Hendriks J M, Bastos Goncalves F, Verhagen H J M
Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Cardiovasc Surg (Torino). 2013 Feb;54(1 Suppl 1):47-53.
Since its introduction more than two decades ago, endovascular aneurysm repair (EVAR) has become the primary choice for elective treatment of abdominal aortic aneurysms (AAA) in many medical centers. The (dis)advantages, including 30-day mortality and long-term survival, of both open and endovascular elective AAA repair have been studied extensively, including four randomized trials. On the contrary, the survival benefit of EVAR for ruptured AAAs is not as well established as in elective situations. In the absence of randomized trials, the best treatment modality for ruptured AAA has not been revealed. In this manuscript, we describe the design and (preliminary) results of recently completed and ongoing randomized trials. Furthermore, the trends in management and the results of the treatment of ruptured AAA in our tertiary center over a 20-year period are presented. In the last decade, a progressive increase in the proportion of patients managed by EVAR was observed. This increase was associated with an overall increase in the number of treated patients and, simultaneously, a decrease in the overall 30-day mortality (53% versus 39%) was seen when comparing the two last decades. The 30-day mortality rates were significantly lower in the patients treated with EVAR (24%) compared to open repair (52%). The survival advantage for EVAR after ruptured AAA persisted during the first 5 years after repair, but was lost after that period. The estimated 5-year survival was 44% and 39% for EVAR and open repair, respectively. These data support that endovascular repair is an effective and safe strategy as a primary treatment modality for ruptured AAA.
自二十多年前引入以来,血管内动脉瘤修复术(EVAR)已成为许多医疗中心择期治疗腹主动脉瘤(AAA)的主要选择。开放性和血管内择期AAA修复术的(优)缺点,包括30天死亡率和长期生存率,已得到广泛研究,其中包括四项随机试验。相反,EVAR治疗破裂性AAA的生存获益并不像在择期情况下那样明确。在缺乏随机试验的情况下,破裂性AAA的最佳治疗方式尚未明确。在本手稿中,我们描述了最近完成和正在进行的随机试验的设计和(初步)结果。此外,还介绍了我们三级中心在20年期间对破裂性AAA的管理趋势和治疗结果。在过去十年中,观察到接受EVAR治疗的患者比例逐渐增加。这种增加与治疗患者总数的总体增加相关,同时,与过去二十年相比,总体30天死亡率有所下降(53%对39%)。接受EVAR治疗的患者(24%)的30天死亡率明显低于开放性修复(52%)。破裂性AAA修复后,EVAR的生存优势在修复后的前5年持续存在,但在此之后消失。EVAR和开放性修复的估计5年生存率分别为44%和39%。这些数据支持血管内修复作为破裂性AAA的主要治疗方式是一种有效且安全的策略。