通过多组分 1,3-偶极环加成反应合成吡咯并[2,1-a]异喹啉。
Synthesis of pyrrolo[2,1-a]isoquinolines by multicomponent 1,3-dipolar cycloaddition.
机构信息
Center of Organic Chemistry "C. D. Nenitzescu", Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania.
出版信息
Molecules. 2013 Feb 27;18(3):2635-45. doi: 10.3390/molecules18032635.
Abstract
Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy.
摘要
吡咯并[2,1-a]异喹啉衍生物是通过一锅法三组分反应从异喹啉、2-溴苯乙酮和不同的非对称炔二极体反应物合成的，使用 1,2-环氧丙烷作为溶剂。通过 IR 和 NMR 光谱对化合物的结构进行了赋值。
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