化学自复制最小模型中的自我调节
Self-regulation in a minimal model of chemical self-replication.
作者信息
Lou Sylvia J, Peacock-López Enrique
机构信息
Department of Chemistry, Williams College, Williamstown, MA 01267 USA.
出版信息
J Biol Phys. 2012 Mar;38(2):349-64. doi: 10.1007/s10867-011-9252-6. Epub 2011 Dec 24.
Abstract
In biological systems, regulation plays an important role in keeping metabolite concentrations within physiological ranges. To study the dynamical implications of self-regulation, we consider a functional form used in genetic networks and couple it to a mechanism associated with chemical self-replication. For the two-variable minimal model, we find that activation can yield chemical toggles similar to those reported for gene repression in E. coli as well as more complex dynamics.
摘要
在生物系统中，调节在将代谢物浓度维持在生理范围内起着重要作用。为了研究自我调节的动力学影响，我们考虑了遗传网络中使用的一种函数形式，并将其与化学自我复制相关的机制相结合。对于双变量最小模型，我们发现激活可以产生类似于大肠杆菌中基因抑制所报道的化学开关以及更复杂的动力学。
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