SPLUNC1 通过 miR-141-PTEN/p27 通路调节细胞的进展和凋亡，但受到 LMP1 的抑制。
SPLUNC1 regulates cell progression and apoptosis through the miR-141-PTEN/p27 pathway, but is hindered by LMP1.
机构信息
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, PR China.
出版信息
PLoS One. 2013;8(3):e56929. doi: 10.1371/journal.pone.0056929. Epub 2013 Mar 5.
Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.
关于宿主防御蛋白短 palate、肺和鼻上皮克隆 1（SPLUNC1）在鼻咽癌（NPC）发生中的作用知之甚少。在这里，我们报告 SPLUNC1 在 NPC 癌变的早期阶段发挥作用。SPLUNC1 通过 miR-141 调节 NPC 细胞的增殖、分化和凋亡，进而调节 PTEN 和 p27 的表达。这个信号轴受 EBV 编码基因 LMP1 的负调控。因此，我们提出 SPLUNC1 抑制 NPC 肿瘤的形成，而 LMP1 的抑制为 NPC 肿瘤发生提供了一条途径。
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