识别有发生出血性转化风险的缺血性中风患者的新方法。
New approach to identify ischemic stroke patients at risk to develop hemorrhagic transformation.
作者信息
Manolescu Bogdan Nicolae, Jickling Glen C
机构信息
"C. Nenitescu" Department Of Organic Chemistry, Faculty of Applied Chemistry and Science of Materials, Polytechnic University of Bucharest, Bucharest, Romania.
出版信息
Maedica (Bucur). 2012 Dec;7(4):352-4.
Some patients with ischemic stroke are subject to hemorrhagic transformation, a complication leading to increased patient morbidity and mortality. The discovery of biomarkers that can be used to identify ischemic strokes prone to this complication are very important for the clinical practice because therapy could be altered to mitigate the risk. We discuss here the results of a trial that evaluated for the first time tight junction proteins as biomarkers of blood-brain barrier disruption and hemorrhagic transformation in ischemic stroke.
一些缺血性中风患者会发生出血性转化，这是一种导致患者发病率和死亡率增加的并发症。发现可用于识别易发生这种并发症的缺血性中风的生物标志物对临床实践非常重要，因为可以改变治疗方法以降低风险。我们在此讨论一项试验的结果，该试验首次评估紧密连接蛋白作为缺血性中风中血脑屏障破坏和出血性转化的生物标志物。
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